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1、 HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html Interleukin HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html RelatedILInterleukins are a group of cytokines (secreted proteins and signaling molecules) that we
2、re first seen to be expressed by whiteblood cells (leukocytes). The function of the immune system depends in a large part on interleukins, and rare deficiencies of anumber of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins aresynthesized
3、 by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote thedevelopment and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in thehippocampus are also known to be involved in the development of s
4、patial memories in mice.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html Interleukin HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html Related HYPERLINK https:/www.MedChemE/Targets/Interleukin Re
5、lated.html HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html Inhibitors, HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html Agonists, HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html HYPERLINK https
6、:/www.MedChemE/Targets/Interleukin Related.html Antagonists, HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html Activators HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html HYPERLINK https:/www.MedChemE/Targets/I
7、nterleukin Related.html & HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html HYPERLINK https:/www.MedChemE/Targets/Interleukin Related.html Modulators HYPERLINK https:/www.MedChemE/1-4-dicaffeoylquinic-acid.html 1,4-Dicaffeoylquinic HYPERLINK https:/www.MedChemE/1-4-dicaffeoylquinic-acid
8、.html HYPERLINK https:/www.MedChemE/1-4-dicaffeoylquinic-acid.html acid(1,4-DCQA) Cat. No.: HY-N0358 HYPERLINK https:/www.MedChemE/13-methylberberine-chloride.html 13-Methylberberine HYPERLINK https:/www.MedChemE/13-methylberberine-chloride.html HYPERLINK https:/www.MedChemE/13-methylberberine-chlor
9、ide.html chloride(13-Methylberberinium chloride) Cat. No.: HY-1258271,4-Dicaffeoylquinic acid (1,4-DCQA) is aphenylpropanoid from Xanthii fructus, inhibitsLPS-stimulated TNF- production.13-Methylberberine chloride (13-Methylberberiniumchloride), a berberine analogue, hasanti-adipogenic and antitumor
10、 activities.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 99.16%Clinical Data: No Development ReportedSize: 5 mg, 10 mg HYPERLINK https:/www.MedChemE/5-s-15-s-dihete.html 5(S)15(S)-DiHETECat. No.: HY-113492 HYPERLINK https:/www.MedChemE/7-3-4-tri-o-methylluteolin.html 7,3
11、,4-Tri-O-methylluteolin(5-Hydroxy-3,4,7-trimethoxyflavone) Cat. No.: HY-N70125(S)15(S)-DiHETE is an “activated” intermediate,inhibits platelet aggregation with an IC of 1.350M. 5(S)15(S)-DiHETE enhances the rate of eitherLXA4 or LXB4 biosynthesis.7,3,4-Tri-O-methylluteolin(5-Hydroxy-3,4,7-trimethoxy
12、flavone), a flavonoidcompound, possesses potent anti-inflammatoryeffects in LPS-induced macrophage cell linemediated by inhibition of release of inflammatorymediators, NO, PGE2, andPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.28%Clinical Data: No Development ReportedSi
13、ze: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/a-9758.html A-9758Cat. No.: HY-126252 HYPERLINK https:/www.MedChemE/ac-yvad-cho.html Ac-YVAD-CHO(L-709049) Cat. No.: HY-120019A-9758 is a ROR ligand and a potent, selectiveRORt inverse agonist (IC =5 nM), and exhibits50robust potency against IL-17A
14、 release. A-9758 iseffective in suppressing both Th17 differentiationand Th17 effector function.Ac-YVAD-CHO (L-709049) is a potent, reversible,specific tetrapeptide interleukin-l convertingenzyme (ICE) inhibitor with mouse and human Kivalues of 3.0 and 0.76 nM. Ac-YVAD-CHO cansuppress the production
15、 of mature IL-l.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/af12198.html AF12198 HYPERLINK https:/www.MedChemE/af12198.html HYPERLINK https:/www.MedChemE/Apilimod.html ApilimodCat. No
16、.: HY-P1110(STA 5326) Cat. No.: HY-14644AF12198 is a potent, selective and specificpeptide antagonist for human type I interleukin-1receptor (IL1-R1) (IC =8 nM) but not the human50type II receptor (IC =6.7 M) or the murine type I50receptor (IC 200 M).50Apilimod (STA 5326) is a potent IL-12/IL-23inhi
17、bitor, and strongly inhibits IL-12 with IC s50of 1 nM and 2 nM, in IFN-/SAC-stimulated humanPBMCs and SAC-treated monkey PBMCs, respectively.Apilimod is a potent and highly selective PIKfyveinhibitor.Purity: 99.61%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.55%Clinical Data: Pha
18、se 2Size: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/apilimod-mesylate.html Apilimod HYPERLINK https:/www.MedChemE/apilimod-mesylate.html HYPERLINK https:/www.MedChemE/apilimod-mesylate.html mesylate HYPERLINK https:/www.MedChemE/apilimod-mesylate.html HYPERLINK https:/www.
19、MedChemE/APY0201.html APY0201(STA 5326 mesylate) Cat. No.: HY-14644ACat. No.: HY-15982Apilimod (STA 5326) mesylate is a potentIL-12/IL-23 inhibitor, and strongly inhibits IL-12with IC s of 1 nM and 2 nM, in50IFN-/SAC-stimulated human PBMCs and SAC-treatedmonkey PBMCs, respectively. Apilimod is a pot
20、entand highly selective PIKfyve inhibitor.APY0201 is a potent PIKfyve inhibitor, whichinhibits the conversion of PtdIns3P toPtdIns(3,5)P in the presence of in the presence of233PATP with an IC of 5.2 nM. APY0201 also50inhibits IL-12/IL-23 production.Purity: 99.40%Clinical Data: Phase 2Size: 10 mM 1
21、mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/armillarisin-a.html Armillarisin HYPERLINK https:/www.MedChemE/armillarisin-a.html HYP
22、ERLINK https:/www.MedChemE/armillarisin-a.html A HYPERLINK https:/www.MedChemE/armillarisin-a.html HYPERLINK https:/www.MedChemE/AX-024.html AX-024Cat. No.: HY-108013 Cat. No.: HY-107390Armillarisin A has the potential for theulcerative colitis (UC) study. Armillarisin Aincreases IL-4 and lower IL-1
23、.AX-024 is an orally available, first-in-classinhibitor of the TCR-Nck interaction thatselectively inhibits TCR-triggered T cellactivation with an IC 1 nM. AX-024 modulates50cell signaling by targeting SH3 domains.Purity: 99.89%Clinical Data: LaunchedSize: 10 mg, 25 mg, 50 mgPurity: 98.0%Clinical Da
24、ta: Phase 1Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/AX-024_hydrochloride.html AX-024 HYPERLINK https:/www.MedChemE/AX-024_hydrochloride.html HYPERLINK https:/www.MedChemE/AX-024_hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/AX-024_hydrochlori
25、de.html HYPERLINK https:/www.MedChemE/Balsalazide.html BalsalazideCat. No.: HY-107390A Cat. No.: HY-B0667AX-024 hydrochloride is an orally available,first-in-class inhibitor of the TCR-Nckinteraction that selectively inhibitsTCR-triggered T cell activation with an IC 150nM. AX-024 hydrochloride modu
26、lates cell signalingby targeting SH3 domains.Balsalazide could suppress colitis-associatedcarcinogenesis through modulation of IL-6/STAT3pathway.Purity: 99.12%Clinical Data: Phase 1Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 99.20%Clinical Data: LaunchedSize: 10 mM 1 mL, 10 mg, 50 mg,
27、 100 mg HYPERLINK https:/www.MedChemE/Balsalazide-sodium-hydrate.html Balsalazide HYPERLINK https:/www.MedChemE/Balsalazide-sodium-hydrate.html HYPERLINK https:/www.MedChemE/Balsalazide-sodium-hydrate.html sodium HYPERLINK https:/www.MedChemE/Balsalazide-sodium-hydrate.html HYPERLINK https:/www.MedC
28、hemE/Balsalazide-sodium-hydrate.html hydrate(Balsalazide disodium dihydrate) Cat. No.: HY-B0667A HYPERLINK https:/www.MedChemE/balsalazide-d4.html Balsalazide-d4Cat. No.: HY-B0667S1Balsalazide sodium hydrate could suppresscolitis-associated carcinogenesis throughmodulation of IL-6/STAT3 pathway.Bals
29、alazide-d4 is deuterium labeled Balsalazide.Balsalazide could suppress colitis-associatedcarcinogenesis through modulation of IL-6/STAT3pathway.Purity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/benralizum
30、ab.html Benralizumab HYPERLINK https:/www.MedChemE/benralizumab.html HYPERLINK https:/www.MedChemE/birt-377.html BIRT HYPERLINK https:/www.MedChemE/birt-377.html HYPERLINK https:/www.MedChemE/birt-377.html 377(MEDI-563; BIW-8405) Cat. No.: HY-P9923Cat. No.: HY-110117Benralizumab (MEDI-563) is an int
31、erleukin-5receptor (IL-5R)-directed cytolytic monoclonalantibody that induces direct, rapid and nearlycomplete depletion of eosinophils via enhancedantibody-dependent cell-mediated cytotoxicity.BIRT 377 is a potent amd orally bioavailableinhibitor of the interaction between intercellularadhesion mol
32、ecule-1 (ICAM-1) and lymphocytefunction-associated antigen-1 (LFA-1), with a Kiof 25.8 nM. BIRT 377 also inhibits the productionof IL-2 in vivo.Purity: 99.1%Clinical Data: LaunchedSize: 1 mg, 2 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/bms-9862
33、51.html BMS-986251 HYPERLINK https:/www.MedChemE/bms-986251.html HYPERLINK https:/www.MedChemE/brd6989.html BRD6989Cat. No.: HY-136527 Cat. No.: HY-122586BMS-986251 is an orally active and selectiveRORt inverse agonist with an EC of 12 nM for50RORt GAL4. BMS-986251 inhibits IL-17 with anEC of 24 nM
34、in human whole blood assay.50BRD6989, an analog of the natural productcortistatin A (dCA), inhibits CDK8 andupregulates IL-10. BRD6989 selectively binds acomplex of CDK8 with an IC of 200 nM. BRD698950inhibits the kinase activity of recombinant CDK8or CDK19 complexes.Purity: 98%Clinical Data: No Dev
35、elopment ReportedSize: 1 mg, 5 mgPurity: 99.85%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/c6-l-threo-ceramide.html C6 HYPERLINK https:/www.MedChemE/c6-l-threo-ceramide.html HYPERLINK https:/www.MedChemE/c6-l-t
36、hreo-ceramide.html L-threo HYPERLINK https:/www.MedChemE/c6-l-threo-ceramide.html HYPERLINK https:/www.MedChemE/c6-l-threo-ceramide.html CeramideCat. No.: HY-116609 HYPERLINK https:/www.MedChemE/cis-mulberroside-a.html cis-Mulberroside HYPERLINK https:/www.MedChemE/cis-mulberroside-a.html HYPERLINK
37、https:/www.MedChemE/cis-mulberroside-a.html A(Mulberroside D) Cat. No.: HY-N0619AC6 L-threo Ceramide is a bioactive sphingolipidand cell-permeable analog of naturally occurringceramides. C6 L-threo Ceramide significantlyinhibits IL-4 production in T cells. Anti-allergicagents.cis-Mulberroside A (Mul
38、berroside D) is thecis-isomer of Mulberroside A. Mulberroside A isone of the main bioactive constituent in mulberry(Morus alba L.).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/
39、daclizumab.html Daclizumab(Zenapax; Ro 24-7375) Cat. No.: HY-108738 HYPERLINK https:/www.MedChemE/deacetylasperulosidic-acid.html Deacetylasperulosidic HYPERLINK https:/www.MedChemE/deacetylasperulosidic-acid.html HYPERLINK https:/www.MedChemE/deacetylasperulosidic-acid.html AcidCat. No.: HY-N0594Da
40、clizumab (Zenapax) is a humanized, monoclonalantibody that blocks CD25 (-subunit of thehigh-affinity interleukin-2 receptor (IL-2R-HA).Daclizumab (Zenapax) reversibly binds to CD25andprevents the interaction of IL-2 with theIL-2R-HA.Deacetylasperulosidic acid (DAA) is a majorphytochemical constituen
41、t of Morinda citrifoliafruit. Deacetylasperulosidic acidhas antioxidantactivity by increasing superoxide dismutaseactivity.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.33%Clinical Data: Phase 4Size: 5 mg, 10 mg, 20 mg HYPERLINK https:/www.MedChemE/Deoxyandrographolide.
42、html DeoxyandrographolideCat. No.: HY-N0857 HYPERLINK https:/www.MedChemE/BMS-986165.html Deucravacitinib(BMS-986165) Cat. No.: HY-117287Deoxyandrographolide suppresses LPS inducedincrease in mRNA levels of iNOS as well asproduction of proinflammatory mediators TNF- andIL-6. Deoxyandrographolide pot
43、entiates NGF-inducedneurite outgrowth.Deucravacitinib (BMS-986165) is a highlyselective, orally bioavailable allosteric TYK2inhibitor for the treatment of autoimmunediseases, which selectively binds to TYK2pseudokinase (JH2) domain (IC =1.0 nM) and blocks50receptor-mediated Tyk2 activation byPurity:
44、 99.87%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 99.79%Clinical Data: Phase 3Size: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg HYPERLINK https:/www.MedChemE/dexanabinol.html Dexanabinol HYPERLINK https:/www.MedChemE/dexanabinol.html HYPERLINK https:/www.MedChemE/di-o-m
45、ethyldemethoxycurcumin.html Di-O-methyldemethoxycurcumin(HU-211) Cat. No.: HY-106387Cat. No.: HY-N7275Dexanabinol (HU-211) is an artificiallysynthesized cannabinoid derivative and lackscannabimimetic effects.Di-O-methyldemethoxycurcumin, a curcuminoidanalog, inhibits IL-6 production with an EC of501
46、6.20 g/mL. Anti-inflammatory and antioxidantproperties.Purity: 98.60%Clinical Data: Phase 3Size: 10 mM 1 mL, 1 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/diacerein.html Diacerein HYPERLINK https:/www.MedChemE/diacerein.html HYPERLINK htt
47、ps:/www.MedChemE/disulfiram.html Disulfiram(Diacerhein; Diacetylrhein) Cat. No.: HY-N0283 (Tetraethylthiuram disulfide; TETD) Cat. No.: HY-B0240Diacerein (Diacerhein), a interleukin-1 betainhibitor, is a slow-acting medicine of the classanthraquinone used to treat joint diseases.Disulfiram (Tetraeth
48、ylthiuram disulfide) is aspecific inhibitor of aldehyde-dehydrogenase(ALDH1), used for the treatment of chronicalcoholism by producing an acute sensitivity toalcohol.Purity: 98.78%Clinical Data: LaunchedSize: 10 mM 1 mL, 50 mg, 100 mgPurity: 99.77%Clinical Data: LaunchedSize: 10 mM 1 mL, 500 mg, 1 g
49、, 5 g4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/dupilumab.html Dupilumab(REGN-668; SAR-231893) Cat. No.: HY-P9926 HYPERLINK https:/www.MedChemE/elubrixin.html Elubrixin(SB-656933) Cat. No.: HY-18263ADupilumab (REGN-668) is a fully human mAb to IL-4recept
50、or (IL-4R) that inhibits both IL-4 and IL-13signaling, markedly improved moderate-to-severeatopic dermatitis.Elubrixin (SB-656933) is a potent, selective,competitive, reversible and orally active CXCR2antagonist and an IL-8 receptor antagonist.Elubrixin inhibits neutrophil CD11b upregulation(IC of 2
51、60.7 nM) and shape change ( of 310.550 IC50nM).Purity: 96.0%Clinical Data: LaunchedSize: 1 mg, 5 mgPurity: 98%Clinical Data: Phase 2Size: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/elubrixin-tosylate.html Elubrixin HYPERLINK https:/www.MedChemE/elubrixin-tosylate.html HYPERLINK https:/www.MedChemE/elu
52、brixin-tosylate.html tosylate(SB-656933 tosylate) Cat. No.: HY-18263C HYPERLINK https:/www.MedChemE/episappanol.html EpisappanolCat. No.: HY-N9315Elubrixin tosylate (SB-656933 tosylate) is apotent, selective, competitive, reversible andorally active CXCR2 antagonist and an IL-8receptor antagonist. E
53、lubrixin tosylate inhibitsneutrophil CD11b upregulation (IC of 260.7 nM)50and shape change (IC of 310.5 nM).50Purity: 99.74%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgEpisappanol is a natural compound isolated fromCaesalpinia sappan heartwood with anti-inflammatorya
54、ctivity. Episappanol significantly inhibits theIL-6 and TNF- secretion.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/etokimab.html Etokimab(Antibody ANB 020) Cat. No.: HY-P99018 HYPERLINK https:/www.MedChemE/gamma-glutamylcysteine-tfa.html Ga
55、mma-glutamylcysteine HYPERLINK https:/www.MedChemE/gamma-glutamylcysteine-tfa.html HYPERLINK https:/www.MedChemE/gamma-glutamylcysteine-tfa.html TFA(-Glutamylcysteine TFA) Cat. No.: HY-113402AEtokimab (Antibody ANB 020) is a humanizedmonoclonal antibody that targets IL-33. Etokimabcan be used for th
56、e research of atopic dermatitis.Gamma-glutamylcysteine (-Glutamylcysteine) TFA,an intermediate in glutathione (GSH) synthesis, isa dipeptide served as an essential cofactor forthe antioxidant enzyme glutathione peroxidase(GPx).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity:
57、98%Clinical Data: No Development ReportedSize: 50 mg, 100 mg HYPERLINK https:/www.MedChemE/GIBH-130.html GIBH-130 HYPERLINK https:/www.MedChemE/GIBH-130.html HYPERLINK https:/www.MedChemE/ginsenoside-f3.html Ginsenoside HYPERLINK https:/www.MedChemE/ginsenoside-f3.html HYPERLINK https:/www.MedChemE/
58、ginsenoside-f3.html F3Cat. No.: HY-101860 Cat. No.: HY-N0600GIBH-130 is an effective inhibitor ofneuroinflammation. GIBH-130 significantlysuppresses the IL-1 secretion by activatedmicroglia (IC =3.4 nM).50Ginsenoside F3, a component of PPTGs (an minorsaponin in the leaves of Panax ginseng), hasimmun
59、oenhancing activity by regulating productionand gene expression of type 1 cytokines (IL-2,IFN-gamma) and type 2 cytokines (IL-4 and IL-10).Purity: 99.95%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 99.84%Clinical Data: No Development ReportedSize: 10 mM 1 mL,
60、1 mg HYPERLINK https:/www.MedChemE/Ginsenoside-Rc.html Ginsenoside HYPERLINK https:/www.MedChemE/Ginsenoside-Rc.html HYPERLINK https:/www.MedChemE/Ginsenoside-Rc.html Rc HYPERLINK https:/www.MedChemE/Ginsenoside-Rc.html HYPERLINK https:/www.MedChemE/Ginsenoside-Rh1.html Ginsenoside HYPERLINK https:/
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