抗性糊精对饱食及体重控制的作用

1、2021/6/161Effect of a resistant dextrin on satiety and weight management抗性糊精对饱食与体重控制的作用抗性糊精对饱食与体重控制的作用Laetitia Deremaux2021/6/162Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饿感饥饿感Food intake食物摄入食物摄入STUDY DESIGN研究设计研究设计Objectives, Study description, Population, Study product administration, Groups,

2、Parameters, Schedule description目的、研究描述、人群、研究产品服法、群组、参数、日程描述目的、研究描述、人群、研究产品服法、群组、参数、日程描述RESULTS结果结果Satiety, Hunger feeling, Caloric & Food intake, Bodyweight, Body fat饱食、饥饿感、热量及食物摄入、体重、体脂饱食、饥饿感、热量及食物摄入、体重、体脂CONCLUSION结论结论Bodyweight体重体重Bodyfat体脂体脂2021/6/163Part IPart I: Study Design: Study Design

3、第一部分第一部分： 研究设计研究设计Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饥饿感饿感Food intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂2021/6/164Study designStudy designObjectives:Evaluation of the impact of a resistant dextrin on satiety, food intake and weight management评价抗性糊精对饱食、食物摄入和体重控制的影响评价抗性糊精对饱食、食物摄入和体重控制的影响Evalu

4、ation of the impact of a resistant dextrin on hunger feeling and body fat评价评价抗性糊精抗性糊精对饥饿感及体脂的影响对饥饿感及体脂的影响Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饥饿感饿感Food intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂2021/6/165Study description (研究描述研究描述) Randomized, placebo-controlled, double-blind, parallel, singl

5、e center随机、安慰剂对照、双盲、平行、单中心随机、安慰剂对照、双盲、平行、单中心 Implemented in China 在中国实施在中国实施Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饥饿感饿感Food intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂Study designStudy design2021/6/166Population (人群人群) 20 healthy overweight Chinese volunteers per group (5 groups 20 volunteers)每组

6、位健康超重中国自愿者（组自愿者）每组位健康超重中国自愿者（组自愿者） Men and women (50/50)男性与女性（）男性与女性（） 35 to 55 years old35 到到 55 岁岁 Overweight (24 BMI 28 kg/m2); Chinese cut-off points for overweight超重（超重（24身体质量指数身体质量指数28公斤米公斤米2）；中国超重切分点）；中国超重切分点 Factory workers工厂工人工厂工人： working 7 days a week at Li Pu manufacturing plant荔浦制造厂每周工作

7、天荔浦制造厂每周工作天 eating at the canteen at every meals每餐在食堂就餐每餐在食堂就餐Study designStudy design2021/6/167Administration (服法服法) Two daily intakes of a resistant dextrin in 250ml orange juice将抗性糊精融入将抗性糊精融入250毫升橙汁，每天摄取两次毫升橙汁，每天摄取两次 Placebo arm: Orange juice安慰剂安慰剂组：组： 橙汁橙汁 Treatment arms: Resistant dextrin at di

8、fferent dosages in orange juice治疗组治疗组：在橙汁中加入不同剂量的抗性糊精在橙汁中加入不同剂量的抗性糊精Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饥饿感饿感Food intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂Study designStudy design2021/6/168Parallel study (平行研究平行研究)Group 1: Placebo组组1： 安慰剂安慰剂Group 2: 4g resistant dextrin 2 intakes = 8g/day组组2

9、： 4克抗性糊精克抗性糊精 2次摄取次摄取 8克天克天Group 3: 7g resistant dextrin 2 intakes = 14g/day组组3： 7克抗性糊精克抗性糊精 2次摄取次摄取 14克天克天Group 4: 9g resistant dextrin 2 intakes = 18g/day组组4： 9克克抗性糊精抗性糊精 2次摄取次摄取 18克天克天Group 5: 12g resistant dextrin 2 intakes = 24g/day组组5： 12克克抗性糊精抗性糊精 2次摄取次摄取 24克天克天Study design研究设计研究设计Satiety饱食饱食

10、Hunger feeling饥饥饿感饿感Food intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂Study designStudy design2021/6/169Schedule descriptionBreakfastBreakfast7:00amLunchLunch12:00-12:30pmDinnerDinner6:30pmPlacebo or resistant dextrinPlacebo or resistant dextrin10:00am4:00pmHunger feeling questionnaire(9:50am)Hunger feeli

11、ng questionnaire(3:50pm)Satiety evaluation (VAS)from 10:00am to 12:00amSatiety evaluation (VAS)from 4:00pm to 6:00pmFood intake evaluation(*)(*)(*)(*)Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饥饿感饿感Food intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂Study designStudy design2021/6/1610Part II: ResultsPart

12、 II: Results第二部分第二部分: : 结果结果 Satiety Satiety 饱食饱食 Hunger feeling Hunger feeling 饥饿感饥饿感Food intakeFood intake 食物摄入食物摄入 Body weight Body weight 体重体重 Body fat Body fat 体脂体脂Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饿感饥饿感Food intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂2021/6/1611Satiety evaluation by VAS

13、Satiety evaluation by VAS饱食评价（按视觉模拟评分法）饱食评价（按视觉模拟评分法）The resistant dextrin has a positive and significant impact on satiety just after the first consumption at 14g, 18g and 24g/day.在首次摄取14克、18克和24克天后，抗性糊精对饱食有积极且明显的影响。DAY 0Orange juice consumptionHunger feeling饥饥饿感饿感Food intake食物摄入食物摄入Bodyweight体重体重B

14、odyfat体脂体脂Study design研究设计研究设计Satiety饱食饱食2021/6/1612Satiety evaluation by VASSatiety evaluation by VAS饱食评价（按视觉模拟评分法）饱食评价（按视觉模拟评分法）DAY 21From day 0 to day 21, the resistant dextrin has shown a progressive and strong impact on satiety. At day 21 and before day 21, the resistant dextrin has shown a sig

15、nificant modulation of satiety at 8g, 14g, 18g and 24g/day.从首日到第从首日到第21日，抗性糊精已显示出对饱食有渐进及较强的影响。在第日，抗性糊精已显示出对饱食有渐进及较强的影响。在第21日及之前日及之前 ，每日摄取，每日摄取8克、克、14克。克。18克及克及24克克/天，抗性糊精已显示出对饱食有明显的调节作用。天，抗性糊精已显示出对饱食有明显的调节作用。Orange juice consumptionHunger feeling饥饥饿感饿感Food intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂Stud

16、y design研究设计研究设计Satiety饱食饱食2021/6/1613Satiety evaluation by VASSatiety evaluation by VAS饱食评价（按视觉模拟评分法）饱食评价（按视觉模拟评分法）The effect of the resistant dextrin on satiety is time correlated and the effects are clear from day 0. 抗性糊精对饱食的作用与时间相关，且从首日开始有作用抗性糊精对饱食的作用与时间相关，且从首日开始有作用 。Orange juice consumptionHung

17、er feeling饥饥饿感饿感Food intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂Study design研究设计研究设计Satiety饱食饱食2021/6/1614The consumption of the resistant dextrin has a positive impact on the hunger feeling score over the study period with a statistical difference from day 5.在研究期间，使用抗性糊精饥饿感评分有正面影响，从第天起有差异。Food intake食物

18、摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饿感饥饿感Hunger feelingHunger feeling饥饿感饥饿感2021/6/1615Hunger feelingHunger feeling饥饿感饥饿感The number of volunteers, who are not hungry, has increased over the study period with a dose-effect relation. 不饿的自愿者人数在研究期间增加，具有量效关系。Food

19、intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饿感饥饿感2021/6/1616Food intakeFood intake食物摄入食物摄入The resistant dextrin has shown a significant decrease in food intake at lunch over the study period, from week 3.从第周期，抗性糊精在研究期间明显减少午餐食物摄入量Bodyweight体重体重Bodyfat体脂体脂Study

20、 design研究设计研究设计Satiety饱食饱食Food intake食物摄入食物摄入Hunger feeling饥饥饿感饿感2021/6/1617BodyBody weightweight体重体重The resistant dextrin has shown a significant decrease in bodyweight from -0.42kg at 14g/day. This weight lost became higher with the increase of the dosage of the resistant dextrin.用量为克天时，抗性糊精明显减少体重

21、 0.42公斤起。随着抗性糊精用量增加，减重更大。Bodyfat体脂体脂Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饥饿感饿感Food intake食物摄入食物摄入Bodyweight体重体重2021/6/1618Body fatBody fat体脂体脂The resistant dextrin has shown a significant decrease in body fat from -0.12% at 18g/day. This body fat decrease became higher with the increase of

22、the dosage of the resistant dextrin.用量为克天时，抗性糊精明显减少体重 .起。随着抗性糊精用量增加，体脂继续减少。Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饥饿感饿感Food intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂2021/6/1619Part IIIPart III: Conclusion: Conclusion第三部分第三部分：结论：结论Study design研究设计研究设计Satiety饱食饱食Hunger feeling饥饿感饥饿感Food intake食物摄入食物摄入Bodyweight体重体重Bodyfat体脂体脂2021/6/1620ConclusionConclusionS SvThere is a logical correlation between the biomarkers leading to an overall improvementvThe daily inclusion of the resistant dextri