国立中兴大学生命科学院 分子生物学研究所 特聘教授推荐表 本

1、國立中興大學生命科學院 分子生物學研究所 特聘教授推薦表 本推薦表共6頁，第1頁姓 名許文輝性 別男出 生 年 月 日民國34年11月26日現 職分子生物學研究所教授兼生命科學院院長身分證號碼略特聘教授聘期 自民國98年8月1日起至100年7月31日止適 用 條 款符合國立中興大學特聘教授設置辦法第三條第一項第 一 款規定。（第一款者得免經學院特聘教授審查小組審查）證 明 文 件曾獲國科會傑出研究獎證明文件。獲本校教學特優教師獎證明文件。獲國科會年度專題研究計畫研究主持費證明文件（近 年 次）。國內外著名學術獎或在國際學術上有傑出貢獻證明文件。學經歷、著作目錄、重要論著、具體學術成就證明及其他

2、相關證明文件。建議獎助金每月新台幣 貳 萬元（第一款）每月新台幣 壹 萬元（第二、三款）每月新台幣 元（第四款）推 薦 理 由國科會93年度傑出研究獎本系所現已獲聘特聘教授人數：0人本學院現已獲聘特聘教授人數：2人聘用單位主管簽章：院長簽章：學院特聘教授審查小組意見推薦，推薦順序： (免經院審) 不推薦 召集人簽章：會辦單位人事室本校特聘教授評審委員會民國 年 月 日學年度 第次會議決議：召集人簽章：校 長 批 示研發處會計室系所聯絡人：蔡艾莉 分機：485轉238本推薦表共6頁，第2頁學歷學校名稱系所修業起訖年月Michigan State Univ.(U.S.A.)Dept. of Mic

3、robiology（博士）1979/ 09至1983/ 02臺灣大學(R.O.C.)植物所微生物組(碩士)1970/ 07至1972/ 06師範大學(R.O.C.)生物系植物組（學士）1965/ 07至1969/ 06經歷服務學校(機關)名稱職稱專 任或兼 任任職起訖年月擔任課程名稱或職務現職：國立中興大學生命科學院分子生物學研究所教授兼院長專 任2007/ 08經歷：國立中興大學分子生物學研究所教授兼所長專 任2004/ 08至2007/ 07經歷：國立中興大學分子生物學研究所教授兼所長專 任1995/ 08至1998/ 07經歷：國立中興大學分子生物學研究所教授專 任1992/ 04食品工

4、業發展研究所菌種保存及研究中心正研究員兼主任專 任1989/ 05至1992/ 03食品工業發展研究所應用微生物組正研究員兼組長專 任1986/ 07至1989/ 05食品工業發展研究所食品科學組研究員專 任1983/ 03至1986/ 06食品工業發展研究所食品微生物組副研究員專 任1972/ 08至1983/ 03重要學術成就或論著國科會專題研究計畫表(C301、C302)最近五年著作目錄(請至人事室網站表格下載區下載)其他特殊成就或造詣目錄 附註：重要學術成就或論著請至少鈎選一項，並以A4格式併推薦表送件。國立中興大學特聘教授最近五年著作目錄一覽表 本推薦表共6頁，第3頁最近五年著作目錄

5、 作者( , corresponding author)著作名稱出版處所或期刊名稱期刊卷期（頁次）出版時間年月期刊論文影響係數備註Lin, L. L., W. H. Hsu, C. P. Wu, M. C. Chi, W. M. Chou, and H. Y. HuA thermostable leucine aminopeptidase from Bacillus kaustophilus CCRC 11223.Extremophiles8:79-8720042.317SCIHsu, S. K., L. L. Lin, H. H. Lo, and W. H. HsuMutational an

6、alysis of feedback inhibition and catalytic sites of prephenate dehydratase from Corynebacterium glutamicum.Archives of Microbiology181:237-24420041.838SCIHua, Y. W., M. C. Chi, H. F. Lo, W. H. Hsu, and L. L. LinFusion of Bacillus stearothermophilus leucine aminopeptidase II with the raw starch-bind

7、ing domain of Bacillus sp. strain TS-23 -amylase generates a chimeric enzyme with enhanced thermostability and catalytic activity.Journal of Industrial Microbiology & Biotechnology31:273-27720041.681SCIWang, W. C., W. C. Chiu, S. K. Hsu, C. L. Wu, C. Y. Chen, J. S. Liu, and W. H. HsuStructural b

8、asis for catalytic racemization and substrates specificity of an N-Acylamino acid racemase homologue from Deinococcus radiodurans.Journal of Molecular Biology342:155-16920044.472SCIChi, M. C., W. M. Chou, W. H. Hsu, and L. L. LinIdentification of amino acid essential for the catalytic reaction of Ba

9、cillus kaustophilus leucine aminopeptidase.Bioscience Biotechnology Biochemistry68:1794-179720041.247SCIChi, M. C., W. M. Chou, C. H. Wang, W. Chen, W. H. Hsu, and L. L. LinGenerating oxidation-resistant variants of Bacillus kaustophilus leucine aminopeptidase by substitution of the critical methion

10、ine residues with leucine.Antonie van Leeuwenhoek International Jouranal of General and Molecular Microbiology86:355-36220041.547SCIHo, L. F., S. Y. Li, S. C. Lin, and W. H. HsuIntegrated enzyme purification and immobilization processes with immobilized metal affinity adsorbents.Process Biochemistry

11、39:1573-158120042.336SCISuen, R. B., S. C. Lin, and W. H. HsuHydroxyapatite-based immobilized metal affinity adsorbents for protein purification.Journal of Chromatography A1048:31-3920043.641SCI本推薦表共6頁，第4頁Lo, H. F., Y. H. Chen, N. W. Hsiao, H. L. Chen, H. Y. Hu, W. H. Hsu, and L. L. LinStabilization

12、 of a truncated Bacillus sp. strain TS-23 -amylase by replacing histidine-436 with aspartate.World Journal of Microbiology & Biotechnology21:411-41620050.745SCILo, H. H., S. K. Hsu, W. D. Lin, N. L. Chan, and W. H. HsuAsymmetrically synthesis of L-homophenylalanine using engineered Escherichia c

13、oli aspartate aminotransferase.Biotechnology Progress21:411-41520052.224SCIChen, C. H., J. C. Cheng, Y. C. Cho, and W. H. HsuA gene cluster for the fatty acid catabolism from Pseudonocardia autotrophica BCRC12444.Biochemical and Biophysical Research Communications329:863-86820052.749SCIHuang, H. B.,

14、 M. C. Chi, W. H. Hsu, W. C. Liang, and L. L. LinConstruction and one-step purification of Bacillus kaustophilus leucine aminopeptidase fused to the starch-binding domain of Bacillus sp. strain TS-23 amylase.Bioprocess Biosyst Eng27:389-39820051.115SCILin, L. L., W. H. Hsu, W. Y. Hsu, S. C. Kan, and

15、 H. Y. HuPhylogenetic analysis and biochemical characterization of a thermostable dihydropyrimidinases from alkaliphilic Bacillus sp. TS-23.Antonie van Leeuwenhoek International Jouranal of General and Molecular Microbiology88:189-19720051.547SCIChen, C. H., H. Y. Hu, Y. C. Cho, and W. H. HsuScreeni

16、ng of compactin-resistant microorganisms capable of converting compactin to pravastatin.Current Microbiology53:108-11220061.167SCIChiu, W. C., J. Y. You, J. S. Liu, S. K. Hsu, W. H. Hsu, C. H. Shih, J. K. Hwang, and W. C. WangStructure-stability-activity relationship in covalently cross-linked N-car

17、bamoyl D-amino acid amidohydrolase and N-acylamino acid racemase.Journal of Molecular Biology359:741-75320064.472SCILin, L. L., P. R. Chou, Y. W. Hua, and W. H. HsuOver-expression, one-step purification, and biochemical characterization of a recombinant glutamyltranspeptidase from Bacillus lichenifo

18、rmis.Applied Microbiology and Biotechnology73:103-11220062.475SCITsai, S. Y., S. C. Lin, S. Y. Suen, and W. H. HsuEffect of number of poly(His) tags on the adsorption of engineered proteins on immobilized metal affinity chromatography adsorbents.Process Biochemistry41:2058-206720062.336SCI本推薦表共6頁，第5

19、頁Hsu, S. K., H. H. Lo, C. H. Kao, D. S. Lee, and W. H. HsuEnantioselective synthesis of L-homophenylalanine by whole cells of recombinant Escherichia coli expressing L-aminoacylase and N-acylamino acid racemase genes from Deinococcus radiodurans BCRC12827.Biotechnology Progress22:1578-158420062.224S

20、CILin, L. L., M. H. Chen, H. R. Chien, S. C. Kan, C. C. Chen, H. Y. Hu, and W. H. HsuCharacterization of a bifunctional aminoacylase/carboxypeptidase from radioresistant bacterium Deinococcus radiodurans R1.Journal of Biotechnology128:322-33420072.565SCILee, Y. C., H. M. Wu, Y. N. Chang, W. C. Wang,

21、 and W. H. HsuThe central cavity from the (Alpha/Alpha)6 barrel structure of Anabaena sp. CH1 N-acetyl-D-Glucosamine 2-epimerase contains two key histidines for reversible conversion.Journal of Molecular Biology367:895-90820074.472SCILee, Y. C., H. R. Chien, and W. H. HsuProduction of N-acetyl-D-neu

22、raminic acid by recombinant whole cells expressing Anabaena sp. CH1 N-acetyl-D-glucosamine 2-epimerase and Escherichia coli N-acetyl-D-neuraminic acid lyase.Journal of Biotechnology129:453-46020072.565SCIHsu, S. K., H. H. Lo, W. D. Lin, I. C. Chen, C. H. Kao, and W. H. HsuStereoselective synthesis o

23、f L-homophenylalanine using the carbamoylase method with in situ racemization via N-acylamino acid racemase.Process Biochemistry42:856-86220072.336SCIOng, P. L., Y. F. Yao, Y. M. Weng, W. H. Hsu, and L. L. LinResidues Arg114 and Arg337 are critical for the proper function of Escherichia coli gamma-g

24、lutamyltranspeptidase.Biochemical and Biophysical Research Communications366:294-30020082.749SCIKao, C. H., H. H .Lo, S. K. Hsu, and W. H. HsuA novel hydantoinase process using recombinant Escherichia coli cells with dihydropyrimidinase and L-N-carbamoylase activities as biocatalyst for the producti

25、on of L-homophenylalanine.Journal of Biotechnology134:231-23920082.565SCIHung, C. P., H. F. Lo, W. H. Hsu, S. C. Chen, and L. L. LinImmobilization of Escherichia coli novablue gamma-glutamyltranspeptidase in Ca-alginate-kappa-carrageenan beads.Applied Biochemistry and Biotechnology150:157-17020081.6

26、43SCI本推薦表共6頁，第6頁Chen, Y. J., W. C. Ku, L. T. Feng, M. L. Tsai, C. H. Hsieh, W. H. Hsu, W. F. Liaw, C. H. Hung, and Y. J. ChenNitric oxide physiological responses and delivery mechanisms probed by water-soluble Roussin's red ester and Fe(NO)210 DNIC.Journal of American Chemical Society130:10929-1

27、093820087.885SCIChen, C. L., T. Y. Pan, S. C. Kan, Y. C. Kuan, L. Y. Hong, K. R. Chiu, C. S. Sheu, J. S. Yang, W. H. Hsu, and H. Y. HuGenome sequence of the lytic bacteriophage P1201 from Corynebacterium glutamicum NCHU 87078: evolutionary relationships to phages from Corynebacterineae.Virology378:226-23220083.765SCIChi, M. C., P. L. Ong, W. H. Hsu, Y. H. Chen, H. B. Huang, and L. L. LinRole of the invariant Asn345 and Asn435 resid