药理学英文习题教研室版

1、.Choice QuestionsType A 1 .The half-life of a drug is 2 hours, how much is the K? A. 0.1 (h-1) B. 0.2 (h-1) C. 0.3 (h-1) D. 0.35 (h-1) E. 2 (h-1) 2. Which of the following statements about first-order kinetics elimination is true? A. The elimination rate is fast B. The elimination rate is slow C. Th

2、ere is no relationship between the amount of drug in the body and elimination rate D. The elimination of drug is in direct proportion to the blood concentration of the drug E. The elimination of drug is in inverse ratio to the amount of drug in the body 3. As far as some drug is concerned, which of

3、the following statements concerning the drug's combination with plasma protein is true? A. The higher the binding rate, the stronger the curative effect B. The lower the binding rate, the stronger the curative effect C. The higher the binding rate, the faster the excretion D. There is not relati

4、onship between binding rate and curative effect E. All of the above are incorrect 4. Which of the following administrations can immediately reach the plateau concentration? A. Decreasing dose, increasing times of administration B. Decreasing administering interval C. Increasing administering interva

5、l D. Administration of loading dose E. Frequent administration by iv5 .In general, the weak acid drugs in basic solution are A. weakly ionized, pass across the biomembrane easily B. strongly ionized, pass across the biomembrane easily C. strongly ionized, pass across the biomembrane hardly D. weakly

6、 ionized, pass across the biomembrane hardly E. all of above are incorrect 6. If the stomach juice pH is1. 4 and plasma pH is 7.4, how much is the drug concentration ratio of plasma to stomach juice for a weak acidic drug with pKa 5.4 when the distribution reach to equilibrium？ A.50 B.100 C.1000 D.1

7、0000 E.0.1 7. All of the following statements are applicable to the sublingual route of administration EXCEPT A. plasma concentration decreased by first pass elimination B. lipid soluble drugs will be absorbed rapidly C. Irritant drugs should not be given by this route D. blood flow through the muco

8、sa is high E. taste of drugs limits the usefulness of this route 8. Which of the following can be advisable to treat hemorrhage of digestive tract? A. Norepinephrine oral administration B. Norepinephrine iv administration C. Norepinephrine im administration D. Norepinephrine subcutaneous injection E

9、. Adrenaline oral administration 9. Phentolamine can most likely be used to treat A. peripheral arterial spasm B. angina pectoris C. arrhythmia D. hypertension E. peptic ulcer 10. Which of the following drugs can be used to treat intoxication of succinylcholine? A. Neostigmine B. Atropine C. Adrenal

10、ine D. Pyraloxime methiodide E. Nikethamide 11. Which of the following drugs can be administered sublingually or inhaled in treating bronchi asthma? A. Adrenaline B. Isoprenaline C. Ephedrine D. Phenylephrine E. Aminophylline 12. After injection of propranolol, the influence of phentolamine on blood

11、 pressure is A. first up, then down B. up only C. down only D. first down, then up E. the same as before 13. Which of the following drugs could pass through the blood-brain barrier and cause insomnia ? A. Adrenaline B. Dopamine C. Ephedrine D. Isoprenaline E. Norepinephrine 14. Which of the followin

12、g is not the contraindication of-receptor blockers?A. chronic heart failureB. atrioventricular blockC. bronchial asthma D. high blood pressureE. sinus bradycardia 15. Which of the following drugs would be used to treat myasthenia gravis? A. Atropine B. Neostigmine C. Acetylcholine D. Scopolamine E.

13、Carbachol 16. Which of the following sympathomimetic agents will most likely lead to arrhythmia and ventricular fibrillation? A. Ephedrine B. Adrenaline C. Metaraminol D. Dopamine E. Norepinephrine 17. In which of the following conditions atropine can most likely be contraindicated A. Glaucoma B. In

14、testinal spasm C. Infective shock D. Iridocyclitis E. All of above 18. Which of the following drugs can be used to treat heart cardiac failure caused by myocardial infarction? A. Atropine B. Isoprenaline C. Dobutamine D. Norepinephrine E. Ephedrine 19. Which of the following drugs is applicable to t

15、reat allergic shock? A. Isoproterenol B. Adrenaline C. Norepinephrine D. Phenoxybenzamine E. Atropine 20 .All of the following statements about the action of neosynephrine are true EXCEPT A. long effective span B. it is stronger than NE in decreasing the renal blood flow C. mydriasis D. it isn't

16、 used to enhance the intraocular pressure E. it can be used to treat paroxysmal supraventricular tachycardia 21. Which of the following drugs can most likely be used to treat infective shock and intractable heart failure? A.Isoprenaline B.Phentolamine C.Phenoxybenzamine D.Reserpine E.Atropine 22. Re

17、nal vasodilation caused by dopamine is because A. it stimulates the renal -receptor B. it stimulates the renal 1-receptor C. it stimulates the renal 2-receptor D. it stimulates the renal DA receptors E. it stimulates the renal DA and M receptors 23. A patient who has "spasms of accommodation&qu

18、ot;、miosis、 increased sweating and excessive salivation may have been given A. a ganglionic blocking drug B. a muscarinic blocking drug C. an anticholinesterase drug D. a 1-adrenoceptor blocking drug E. an -adrenoceptor blocking drug 24. Which of the following therapeutic projects would be used in t

19、he treatment of patient with serious organophosphate intoxication? A. Atropine B. Atropine + neostigmine C. Atropine + pyraloxime methoiodide D. Atropine + norepinephrine E. Pyraloxime methoiodide 25. Which of the following drugs can be used in treating the patient with atrioventricular block?A. adr

20、enalineB. noradrenalineC. isoprenalineD. aramineE. propranolol26. Which of the following M-receptor blockers can be used in the treatment of motion sickness and Parkinsonism?A. atropineB. anisodamineC. scopolamineD. homatropineE. propantheline27. When phenobarbital poisoning, in order to reducing to

21、xicity and promoting toxic substance excretion, we should A. apply acidic drug to decrease the pH of plasma and urine B. apply basic drug, to increase the pH of plasma and urine C. infuse intravenously dextran 40 D. administer normal saline solution E. administer 10% glucose intravenously28. Which o

22、f the following statements about extrapyramidal syndrome caused by chlorpromazine is correct? A. Blocking of DA receptors on nigrostriatal pathway B. Blocking of DA receptors on middle brain-limbic system pathway C. Blocking of DA receptors on middle brain-cortex pathway D. Blocking of DA receptors

23、on nodule infundibular pathway E. All of the above are incorrect 29. Lithium carbonate can be used in treating maniac because A. it increases the release of NA in brain B. it inhibits the release of NA and DA, and promotes the reabsorption of NA and DA C. it increases the synthesis of NA in brain D.

24、 it decreases the synthesis of NA in brain E. it decreases the synthesis of NA and DA in brain 30. Which of the following is the drug choice for status epilepticus? A. phenobarbital B. phenytoin sodium C. valproate sodium D. carbamazepine E. diazepam 31. To treat cardiac asthma we can select A. isop

25、renaline B. asdrenaline C. pethidine D. atropine E. ephedrine 32. Which of the following analgesic drugs can be used in artificial hibernation? A. pethidine B. morphine C. anadol D. methadone E. fentanyl 33. The analgesic mechanism of morphine is A. inhibition of morphine receptors in brain B. block

26、ing morphine receptors in center C. stimulating morphine receptors in center D. inhibition of synthesis of PG in brain E. all of above are incorrect 34. The drug that can be used in treating patients with various depression is A. chlorpromazine B. promethazine C. imipramine D. lithium carbonate E. t

27、rifluperazine 35. Which of the following about saving the phenobarbital poisoning is INCORRECT? A. Infusing normal saline solution in a large dose B. Administration of sodium bicarbonate to basify urine C. Administration of strong diuretics D. Administration of ammonium chloride to acidify the body

28、fluid and urine E. Washing the stomach in poisoning early 36. Which of the following statements about the mechanism of aspirins antipyretic effect is true? A. Inhibition of PG synthesis of temperature regulating center B. Inhibition of DA synthesis of temperature regulating center C. Promoting of PG synthesis of the temperature-regulating center D