北京协和建昊医药技术开发有限责任公司

1、北京协和建昊医药技术开发有限责任公司Beijing Uuion-Genius Pharmaceutical Technology Ltd 项目领域Testing field序号No.项目名称Name of study方法号Method codeOECD编号OECD code所需样品量（克）Needed sample(g)所需时间（天）Needed Time(d)健康毒理Health Effects1急性经口毒性试验Acute Oral Toxicity Test4014012030282急性经皮毒性试验Acute Dermal Toxicity Test4024021020283急性吸入毒性试

2、验Acute Inhalation Toxicity Test4034032030284急性皮肤刺激性/腐蚀性试验Acute Dermal Irritation/Corrosion Test4044041020285急性眼刺激性/腐蚀性试验Acute Eye Irritation/Corrosion Test4054051020286皮肤致敏试验Skin Sensitization Test4064062030407啮齿类动物28天反复经口毒性试验Repeated Dose 28-day Oral Toxicity Study in Rodents4074076008001508啮齿类动物亚慢

3、性（90天）经口毒性试验Repeated Dose 90-day Oral Toxicity in Rodents408408100020002109非啮齿类动物亚慢性（90天）经口毒性试验Repeated Dose 90-day Oral Toxicity in Nonrodents4094092000400021010反复经皮毒性：21/28天试验Repeated Dose Dermal Toxicity:21/28-day Study41041060080015011亚慢性经皮毒性：90天试验Subchronic Dermal Toxicity: 90-day Study41141110

4、00200021012反复吸入毒性：28天或14天试验Repeated Dose Inhalation Toxicity: 28/14-day Study41241260080015013亚慢性吸入毒性：90天试验Subchronic Inhalation Toxicity: 90-day Study4134131000200021014致畸试验Teratogenicity41441450080012015一代繁殖毒性试验One-Generation Reproduction Toxicity Study4154151000200018016两代繁殖毒性试验Two- Generation Re

5、production Toxicity Study4164161000200024017毒物动力学试验Toxicokinetics Study41741720040012018有机磷化合物急性染毒的迟发性神经毒性试验Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure41841830409019有机磷化合物亚慢性（28天）染毒的迟发性神经毒性实验Delayed Neurotoxicity of Orgarophosphorus Substances: 28-day Repeated Dose

6、Method41941920040015020急性经口毒性：固定剂量法Acute Oral Toxicity-Fixed Dose Method42042020402821生殖和发育毒性筛选试验Reproduction/Developmental Toxicity Screening Test42142130050015022结合反复染毒毒性研究的生殖发育毒性筛选试验Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test42242250080021023急

7、性经口毒性：急性毒性的阶层法Acute Oral Toxicity-Acute Toxic Class Method42342350604024啮齿类动物的神经毒性试验Neurotoxicity Study in Rodents4244243005009025急性经口毒性：上下增减剂量法Acute Oral Toxicity: Up and Down Procedure42542550604026致癌试验Carcinogenicity Studies4514515000800072027慢性毒性试验Chronic Toxicity Studies4524523000600036028慢性毒性与

8、致癌性联合试验Combined Chronic Toxicity/Carcinogenicity Studies4534535000800072029细菌回复突变试验Bacterial Reverse Mutation Test471， 472471， 47210206030体外哺乳动物细胞染色体畸变试验In vitro Mammalian Chromosome Aberration Test47347310206031哺乳动物红细胞微核试验Mammalian Erythocyte Micronucleus Test47447430503532哺乳动物骨髓染色体畸变试验Mammalian Bo

9、ne Marrow Chromosome Aberration Test47547510206033体外哺乳动物细胞基因突变试验In vitro Mammalian Cell Gene Mutation Test47647610209034黑腹果蝇伴性隐性致死试验Sex-linked Recessive Lethal Test in Drosophila Melanogaster, SLRL47747710209035啮齿类动物显性致死试验Rodent Dominant Lethal Test4784782004009036哺乳类动物细胞姐妹染色单体互换体外试验In vitro Sister

10、Chromatid Exchange Assay in Mammalian Cells47947910209037酿酒酵母基因突变试验Saccharomyces cerevisiae, Gene Mutation Assay48048010206038酿酒酵母有丝分裂重组试验Saccharomyces Cerevisiae Mitotic Recombination Assay48148110206039哺乳类动物细胞DNA损害与修复/程序外DNA合成体外试验DNA Damage and Repair/Unscheduled DNA Synthesis in Mammalian Cells i

11、n vitro48248210209040哺乳动物精原细胞染色体畸变试验Mammalian Spermatogonial Chromosome Aberration Test48348310209041小鼠斑点试验Mouse Spot Test4844841002009042小鼠可遗传易位试验Mouse Heritable Translocation Assay4854852004009043体内哺乳动物肝细胞程序外DNA合成（UDS）试验Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo4864861

12、0209044空斑形成细胞试验（PFC）Plaque Forming Cell Assay49049010209045迟发型超敏反应试验Delayed Type Hypersensitivity Test4914911002009046自然杀伤细胞活性试验Natural Killer Cell Activity Assay492492102090理化性质Physical-chemical property47紫外-可见吸收光谱US-VIS Absorption Spectra10110110060 48熔点/熔点范围 Melting Point/Melting Range10210210030

13、 49沸点 Boiling Point10310320060 50蒸汽压 Vapour Pressure104104100180 51水溶解度 Water Solubility10510510090 52吸附/解析 Adsorption/Desorption10610650120 53分配系数（正辛醇/水）-摇瓶法Partition Coefficient(n-octanol/water-Polarographic Method)10710710090 54液体和固体的密度 Density of Liquids and Solids109109200ml/200g60 55颗粒物粒度分布/纤维

14、长度和直径分布 Particle Size Distribution/Fibre Length and Diameter Distributions11011010060 56与PH有关的水解作用Hydrolysis as a Function of Ph11111150300 57分配系数（正辛醇/水）-高效液相色谱法 Partition Coefficient(n-octanol/water-HPLC Method1171175090 生态毒理Eco-toxicity58藻类生长抑制试验 Alga Growth Inhibition Test2012012060 59溞类24hEC50急性

15、活动抑制试验 Daphnia sp. 24h EC50 Acute Immobilization Test2022022045 60鱼类急性毒性试验 Fish Acute Toxicity Test203203200100 61鱼类14天延长毒性试验 Fish, Prolonged Toxicity Test: 14-day Study204204200100 62鸟类日粮毒性试验 Avian Dietary Toxicity Test2052052514 63鸟类繁殖试验Avian Reproduction Test20620623090 64蚯蚓急性毒性试验Earthworm, Acute

16、 Toxicity Test2072077090 65活性污泥呼吸抑制试验 Activated Sludge, Respiration Inhibition Test2092092045 66大型溞繁殖试验 Daphnia magna Reproduction Test211211200180 67蜜蜂急性经口毒性试验Honeybees, Acute oral Toxicity Test21321310090 68蜜蜂急性接触毒性试验 Honeybees, Acute Contact Toxicity Test21421410060 69快速生物降解性 Ready Biodegradabili

17、ty3013011090 70改进的MITI试验（I）Modified MITI Test I301C301C10100 71密闭瓶试验Closed Bottle Test301D301D10100 72改进的OECD筛选试验 Modified OECD Screening Test301E301E10100 73改进的半连续活性污泥（SCAS）试验 Inherent Biodegradability: Modified SCAS Test302A302A20100 74改进的MITI试验（II） Modified MITI Test II302C302C20100 75土壤固有生物降解能力 Inherent Biodegradability in Soil304A304A100120 76流水式鱼类试验 Bioconcentration:Flow-Through Fish Test3053051000210 77连续静态鱼类试验Bioconcentration: Sequential Static Fish Te