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1、From Cinderella to Princess - beyond manuscript Dear Editor: I am writing to submit a manuscript, entitled “”, to your prestigious journal. . E-mail: ; Tel:Dear Dr. Miczek: We intend to publish our paper, entitled “”, in Neuropsychopharmacogy. E-mail: ; Tel:Journal Select

2、ion impact factor vs. penetration E-mail: ; Tel:1)多巴胺)多巴胺4型受体在多动症模型上调型受体在多动症模型上调 E-mail: ; Tel:1)多巴胺)多巴胺4型受体在多动症模型上调型受体在多动症模型上调 2)多巴胺)多巴胺4型受体拮抗剂减轻多动症状型受体拮抗剂减轻多动症状 E-mail: ; Tel:Dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamin

3、e lesions in rats 候选杂志候选杂志 影响因子影响因子 - PNAS Journal of Neuroscience Neuropsychopharmacology Behavioral Neuroscience - E-mail: ; Tel:Dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats 候选杂志候选杂志 杂志领域杂志领域 - PNAS 包罗万象包罗万象 - E-mail: ; Tel: 021-6

4、1390110 Dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats 候选杂志候选杂志 杂志领域杂志领域 - PNAS Journal of Neuroscience 包罗万象包罗万象 神经科学(基础)神经科学(基础) - E-mail: ; Tel:Dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesio

5、ns in rats 候选杂志候选杂志 杂志领域杂志领域 - PNAS Journal of Neuroscience Neuropsychopharmacology 包罗万象包罗万象 神经科学(基础)神经科学(基础) 神经精神药理(临床、基础)神经精神药理(临床、基础) - E-mail: ; Tel:Dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats 候选杂志候选杂志 杂志领域杂志领域 - PNAS Journal o

6、f Neuroscience Neuropsychopharmacology Behavioral Neuroscience 包罗万象包罗万象 神经科学(基础)神经科学(基础) 神经精神药理(临床、基础)神经精神药理(临床、基础) 行为神经科学(基础)行为神经科学(基础) - E-mail: ; Tel:Dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats 候选杂志候选杂志 穿透力穿透力 - PNAS 差差 - E-mail

7、: ; Tel:Dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats 候选杂志候选杂志 穿透力穿透力 - PNAS Journal of Neuroscience 差差 偏偏 - E-mail: ; Tel:Dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in ra

8、ts 候选杂志候选杂志 穿透力穿透力 - PNAS Journal of Neuroscience Neuropsychopharmacology 差差 偏偏 强强 - E-mail: ; Tel:Dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats 候选杂志候选杂志 穿透力穿透力 - PNAS Journal of Neuroscience Neuropsychopharmacology Behavioral Neuros

9、cience 差差 偏偏 强强 很强很强 - E-mail: ; Tel:Dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats 候选杂志候选杂志 穿透力穿透力 影响因子影响因子 - PNAS Journal of Neuroscience Neuropsychopharmacology Behavioral Neuroscience - E-mail: ; Tel:Zhang K, Tarazi

10、FI, Baldessarini RJ: Role of dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats. Neuropsychopharmacology, 25:624632, 2001 Zhang K, Tarazi FI, Davids E, Baldessarini RJ: Plasticity of dopamine D4 receptors in rat forebrain: Temporal association with mot

11、or hyperactivity following neonatal 6-hydroxydopamine lesioning. Neuropsychopharmacology, 26:625633, 2002 E-mail: ; Tel:Zhang K, Tarazi FI, Baldessarini RJ: Role of dopamine D4 receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats. Neuropsychopharmacolo

12、gy, 25:624632, 2001 Zhang K, Tarazi FI, Davids E, Baldessarini RJ: Plasticity of dopamine D4 receptors in rat forebrain: Temporal association with motor hyperactivity following neonatal 6-hydroxydopamine lesioning. Neuropsychopharmacology, 26:625633, 2002 Zhang K, Grady CJ, Tsapakis EM, Andersen SL,

13、 Tarazi FI, Baldessarini RJ: Regulation of working memory by dopamine D4 receptor in rats. Neuropsychopharmacology, 29:16371647, 2004 E-mail: ; Tel:Dear Dr. Zhang: I am writing this letter to invite you to join the Pharmacology for Neuropsychiatric Disorders Small Business study sectio

14、n of the National Institutes of Health. Your expertise would be most helpful in doing a fair and objective review of the grant applications. Jerome R. Wujek, PhD Scientific Review Administrator National Institutes of Health Center for Scientific Review E-mail: ; Tel:How to respond to r

15、eviewer comments - the art of “butter up” E-mail: ; Tel:Reviewer: The D4 receptor assay is invalid. The radioligand 3Hnemonapride labels all members of the D2-like receptors, including the D2, D3, and D4 receptors. Admittedly, the authors made an attmpt to occlude binding of 3Hnemonapr

16、ide to D2 and D3 receptors with raclopride. However, the D2 receptor is far more abundant than the D4 receptor. As a result, the claim that this is a D4 receptor assay is invalid. E-mail: ; Tel:We understand the reviewer concern. The D2 receptor is indeed far more abundant than the D4

17、receptor in rat brain (roughly 100 fold; ref #1). We did, however, carried out a carefully designed experiment in purified receptors and demonstrated that at 300 nM (the concentration used in our assay), raclopride eliminates 99.9% of the binding of 3Hnemonapride to D2 receptor without affecting its

18、 binding to D4 receptor. Such data were published in a previous report from this laboratory (ref #2), and comfirmed by a group led by Nemoroff and colleagues (ref #3). Based on these findings, we do believe that the assay in our study . E-mail: ; Tel:How to respond to reviewer comments - the art of “butter up” ? Never confront reviewer ? Argue with support (facts & references) ? Psychology is everything Find a pleasant

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