最新药理学课件南开大学第十五章影响自体活性物质的药物PPT文档

1、histamine and antihistamine agentshistamine and its agonistshistamine antagonistsh1 receptor antagonistsh2 receptor antagonists together with endogenous peptides, prostaglandins and leukotrienes, and cytokines, they are sometimes called autacoids or local hormones bronchoconstriction and contraction

2、 of intestinal s.m. expand blood vessel permeabilitystimulate sensory nerve endings cause gastric acid, gastric pepsin and intrinsic factor production. cause a decrease in systolic and diastolic blood pressure and a increase in heart rate. bronchoconstriction and contraction of intestinal s.m. expan

3、d blood vessel permeabilitystimulate sensory nerve endings cause gastric acid, gastric pepsin and intrinsic factor production. cause a decrease in systolic and diastolic blood pressure and a increase in heart rate. intradermal injection of histamine causes a characteristic wheal-and-flare response,

4、which involves an erythema, an edematous wheal and a red irregular flare surrounding the wheal. to be used in testing gastric acid secretion and diagnosis of leprosy.decrease of gastric acid can be seen in malignant anemia and true achlorhydiahistamine and antihistamine agentshistamine and its agoni

5、stshistamine antagonistsh1 receptor antagonistsh2 receptor antagonistshistamine and antihistamine agentshistamine and its agonistshistamine antagonistsh1 receptor antagonistsh2 receptor antagonistsfirst-generation blockerssecond-generation blockers urapidly absorbed orallyuwidely distributed and the

6、 first-generation drugs enter the cns readily.umost metabolized in the liver umost excreted from the kidney bronchoconstriction and contraction of intestinal s.m. expand blood vessel permeabilitystimulate sensory nerve endings cause gastric acid, gastric pepsin and intrinsic factor production. cause

7、 a decrease in systolic and diastolic blood pressure and a increase in heart rate. sedation, antimuscarinic action, drug allergy, cardiac arrhythmias (astemizole) and possible teratogenic effects.histamine and antihistamine agentshistamine and its agonistshistamine antagonistsh1 receptor antagonistsh2 receptor antagonists bronchoconstriction and contraction of intestinal s.m. expand blood vessel permeabilitystimulate sensory nerve endings cause gastric acid, gastric pepsin and intrinsic factor production. cause a decrease in systolic and diastolic blood pressure and a