免疫习题 免疫细胞及其相关分子（Immune exercises, immune cells and related molecules）

1、免疫习题 免疫细胞及其相关分子（Immune exercises, immune cells and related molecules）Immune exercises, immune cells and their associated molecules,.Txt, marry, are like wearing a cotton padded coat for free. Its not easy to move, but its very warm. Falling in love is like peeling onions. Theres always a layer of te

2、ars going on. First, the multiple-choice question:1. human B lymphocyte surface hasA. sheep erythrocyte receptor B.FceR, C.CR2, D.HIV receptor, class E.MHC, class II receptorThe earliest sign of 2.B cell differentiation isA.Ig gene DNA rearrangement, B. cytoplasm, IgM, C. membrane, IgD appearD. memb

3、rane, IgM expression, E., light chain synthesis3. human B lymphocyte surface does not appearA.MHC class I molecules, class B.MHC, class II molecules, C.C3b receptorsD.EBV receptor, E., sheep erythrocyte receptor4. which cytokines are not produced by macrophages?A.IL-1, B.IL-3, C., IFN-a, D., IFN-g,

4、E., TNF-a5. It can be activated by PHA. It has antigen specific receptor, and can form rosette with SRBC, and can produce secondary response. According to the biological changes mentioned above, T and B lymphocytes can be distinguishedA. + + B. + + C., + + D. + + + E. + +6. which of the following ce

5、lls appear in the thymus medulla?A.CD3+, CD8-, CD4-, B.CD3+, CD4+, CD8+, C.CD3+, CD4+, CD8-D.CD3-, CD4-CD8-, E.CD3-, CD4+, CD8-7. Low molecular weight secretory proteins are expressed on the surface of the cell membrane, autocrine and paracrine, and have broad biological activity. What are the chara

6、cteristics of cytokines in the above points?A. + + B. + + C. + + + D. + E. + +8. B cell antigen receptor is Ig, the T cell antigen receptor consists of two peptides, T, B cell receptor signaling molecules are attached, the T cell antigen receptor binding site is super antigen. Which group is the cor

7、rect description of the antigen receptor described above?A. + + B. + + C. + + + D. + E. + +9. CD molecules that bind to TCR areA.CD1, B.CD3, C.CD8, D.CD4, E.CD210. membrane molecules that do not appear at all stages of B cell development areA.IgM, B.CD2, C.IgD, D.FcgR, E.C3bR11., IL-2, IL-3, IL-4, I

8、L-5. What cytokines are produced by TH1?A. + + B., C. + + + D. + + E. + +12. cells that can recognize antigens specifically areA.MF, T, B., MF, B, C.T, B, D., NK, MF, E.T, NK13. which of the following cells express MHC class II molecules?A. quiescent B cells, B. quiescent T cells, C. quiescent NK ce

9、llsD. stationary neutrophil E. eosinophils14. occurred in the thymus cortex, a large number of double positive cell death, and complete the process of cloning and elimination, and the double positive cells differentiated into single positive cells. What are the processes associated with positive sel

10、ection?A. + + B. + + C. + + + D. + + E.15. Thymic cortex, thymus medulla region, lymphocyte sub cortex area, splenic lymph tissue.CD4+CD8+ cells may appear in areas that areA. + B. + + + C. + + D. + + E.16. 、 the difference between B cell and MF is that there is FcgR on its surface,The difference be

11、tween B cells and T cells is that there are different antigen receptors,The difference between B cells and NK cells is that they can be swallowed,The difference between B cell and MF is that its cytotoxicity is specific.Which of the above is true?A. + + B. + C. + + D., E. + +17.TH1 differs from TH2

12、cells becauseA. the former CD4+, and the latter CD4-B. the former produces IL-4, and the latter produces IL-5C. the former produces IFN-a, and the latter produces IFN-bThe former D. aids the occurrence of delayed hypersensitivity, and the latter contributes to the occurrence of rapid hypersensitivit

13、yE. the former receives activation of the TI antigen and the latter receives the activation of the TD antigen18. signal transduction molecules that constitute the BCR complex areA.IgD, IgM, B.Iga, Igd, C.Igb, Iga, D.Ige.Igd, E.Igb, Igh19. which of the following cells should be excluded from full-tim

14、e APC?A.Helper T cells B. macrophage C. E. dendritic cells D.B cells of Langerhans cells20., a complex signal transduction molecule, which binds directly to free antigen, binds only to peptide antigen. The coding gene needs to be rearranged by gene. What are the differences between TCR and BCR?A. +

15、+ + B. + + C. + + D. + + E. + IIWhat kind of cell surface does 21.CD40L mainly exist on?A.MF B.B cell, C.TH cell, D.NK cell, E. endothelial cell22. in the process of TH cell activation, the non functioning surface molecules of the cell membrane areA.CD28, B.CD8, C. CD4, D.CD3, E.TCR23. Development h

16、as nothing to do with bone marrow, CD5+, and the cell membrane expresses MHC class II molecules, and only IgM type antibody is produced.What are the correct descriptions of B1 cells?A. + + B. + + C., + + + D. + + E. + + +24. 、 the ability of anti viral immunity decreased, and no graft rejection occu

17、rred. Still, delayed hypersensitivity could be produced. Peripheral blood B lymphocyte was decreased. Appeal to the case of congenital thymic miceA. + + B. + + C. + D. + + E. + +25.TCRa/b two merA. is covalently linked to MHC class I moleculesInteraction between B. and CD2 moleculesC. is not covalen

18、tly linked to the CD3 moleculeD. is the first surface marker in the differentiation and maturation of T cellsCompared with SmIg, E. has more diversity26., there was a specific response to the antagonism. The antigen was enriched on the surface of the cell. It was found in the follicles and germinal

19、centers of the lymph nodes and existed in the white pulp of the spleen. Which of these are T and B lymphocytes in common?A. + + B. + + C. + + D. + + E.;27. which of the following fits the clonal selection theory?Receptors on the surface of A. lymphocytes produce specificity by contact with the antig

20、enThe pre T and pre B cells in the B. bone marrow have a fixed specificityC.B cells must undergo gene induced mutations to complete gene rearrangementThe contact between D.T cell and APC is the premise of clonal selectionE. immature T and B cells can be removed by exposure to antigens28., PHA, LPS,

21、ConA, PWM. Which of these are the mitogens of human T cells?A. + + B., + + C., + + D., + + E. + + +29. which of the following conditions does not occur in patients with congenital cystic organ defect?A. lymph node lacks germinal centerB. circulating lymphocytes have no SmIg markersIn C. lymph nodes,

22、 the number of secondary cortical cells decreasedD. tonsil atrophyE. decreased splenic plasma30. which of the following is not associated with the antigen presenting function of APC?A. expresses sufficient MHC moleculesB. antagonism, phagocytosis, treatmentC. forms and produces antibodiesD. produces

23、 certain cytokinesE. expresses a specific costimulatory factor31. of the peripheral blood, T cells accounted for the total number of lymphocytesA.1020%B.2030%C.4050%D.6080%E.5%32. of the peripheral blood, B cells accounted for the total number of lymphocytesA.1015%B.2025%C.3040%D.6080%E.5%33. 、 dire

24、ct binding of free antigen, we must recognize the antigen peptide binding with MHC molecule, identify the spatial configuration determinant of epitope, and identify the linear peptide fragment of antigen. What are the characteristics of the BCR identification antigen?A. + + B. + + C. + + D. + E.34.

25、T cells acquire specific antigen receptor sites, T cells react to specific antigens, T cells assist B cells to produce antibodies, and T cells die in large numbers. About the thymus, which of the above description is correct?A. + + B. + + C. + + D. + E.35. which of the following is a correct descrip

26、tion of TCR?A. can only appear on the surface of CD4+ cellsB. consists of four peptide chains a, B, G, and DC. identifies complexes formed by CD8 molecules with antigenic peptidesD. is complementary to the determinant of complete antigen formationE. is a link between APC and T cellsThirty-sixWhat ar

27、e the two peptide chains that make up TCR?AA, II, AB, GG, GDA. + + B. + + C. + + D. + + E. + +Answer：1.C, 2.A, 3.E, 4.D, 6.C, 7.E, 9.B, 10.B, 11.A, 13.A, 14.B, 15.E, 16.B, 17.D, 18.C, 19.A, 20.B, 21.C, 22.B, 23.E, 24.A, 25.C, 26.C, 27.E, 28.D, 29.C, 30.C, 31.D, 12.C, 32.A, 8.E, 33.D, 5.C, 34.E, 35.E

28、, 36.CTwo fill in the blanks1, T and B lymphocytes are the two most important cells in immune response.2, T cells are defined as differentiated and mature lymphocytes.3 in the bursa of Fabricius (avian) or bone marrow (mammalian), the lymphocyte as the central immune organ is the cell.The region of

29、4 and TCR is the site of antigen specific binding.5. Most TCR consist of alpha and beta chains, and a few TCR are made up of chains and chains.6 and CD3 molecules combine with TCR to form complexes, which have the function of TCR structure and signal.7, according to different, T cells can be divided

30、 into CD4+ and CD8+ two subpopulations.8, CD4 molecules combine with sites of class MHC molecules.9. Cell surface molecules that bind to non polymorphic regions of class MHC-I molecules are.10, for T cell activation, CD28 molecules receive signals.11 、 the T cell belongs to the IFN- cell group mainl

31、y containing IL-2, gamma and other cytokines12 、 the T cell belongs to the B cell group which mainly produces the antibody.13, IL-4 and IL-5 producing T cell belongs to the cell group.14, double negative phase is in the thymus of T cells, neither the expression of molecules, but not to express the m

32、olecular stage of development.15, the CD4+ CD8 - cell in the medulla of the thymus is called T cell.16 and BCR are the molecular structures of B cell surface and the same membrane surface globulinIn the 17 and BCR complexes, CD3 like molecules are composed of two distinct dimers.18. Lymphocytes lack

33、ing antigen receptors are cells.19, the antigen peptide and class MHC-II molecular complex presented to the T cells, known as.20, B cells can express class MHC-II molecules, but also cells.21. Interleukin is a small molecular polypeptide secreted by cells that regulates or functions of cells.22. The

34、 membrane molecules that mediate the interaction between cells, cells and the stroma are called.Answer：1. immunocompetent cells2. thymus3. B4. V5. gamma, Delta6., stable, transmitted antigen stimulation7. surface antigen (surface molecule)8. II, non polymorphism9. CD810. co stimulation (co stimulation, second)11. TH112. TH213. TH214. CD4, CD815. single positive16. immunoglobulin (Ig)17. Ig alpha, Ig beta18. NK19. antigen presenting cell (APC)20. antigen presentation21. self, other22. adhesion moleculesThree. Noun explanation1 、 leucocyte differentiation antigen2, cytokines3 、