VEGFR-2-IN-62-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEVEGFR-2-IN-62Cat.No.:HY-170662分⼦式:C₂₆H₁₈ClN₅O₂分⼦量:467.91作⽤靶点:Apoptosis;Bcl-2Family;VEGFR作⽤通路:Apoptosis;ProteinTyrosineKinase/RTK储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性VEGFR-2-IN-62(Compound3f)⼀种有效的VEGFR-2抑制剂，其IC50值为0.0557μM。VEGFR-2-IN-62能抑制细胞增殖，并诱导细胞凋亡(Apoptosis)，可以⽤于癌症的研究[1]。IC50&TargetVEGFR-20.0557μM(IC50)体外研究VEGFR-2-IN-62(Compound3f)(0.08μM;24h)caninduceapoptosisinMCF-7cells,significantlyincreasingBaxlevelsanddownregulatingBcl2levels,whilegreatlyincreasingtheBax/Bcl2ratio[1].VEGFR-2-IN-62exhibitsantiproliferativeactivityagainstHepG2,MCF-7andVEROhumantumorcelllines,withIC50valuesof0.17,0.08and1.98μM,respectively[1].VEGFR-2-IN-62(2.3μM;24h)canarresttheMCF-7cellcycleattheG2-Mphase[1].ApoptosisAnalysis[1]CellLine:MCF-7Concentration:0.08μMIncubationTime:24hResult:Encouragedearlyapoptosis(21.44%)bymorethan36foldsoverthecontrol(0.59%).CellCycleAnalysis[1]CellLine:MCF-71/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEConcentration:2.3µMIncubationTime:24hResult:CausedcellstoarrestgrowthintheG2-Mphase;theaccumulationproportionofcellsatthisphasechangedfrom13.2%inthecontrolgroupto9.08%.REFERENCES[1].BayoumiHH,etal.PhthalazineDerivativesasVEGFR‐2Inhibitors:Docking,ADMET,Synthesis,Design,AnticancerEvaluations,andApoptosisInducers[J].DrugDevelopmentResearch,2025,86(1):e70037.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58