Pentagalloylglucose-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPentagalloylglucose(Standard)Cat.No.:HY-N0527RCASNo.:14937-32-7分⼦式:C₄₁H₃₂O₂₆分⼦量:940.68作⽤靶点:JAK;Keap1-Nrf2;Apoptosis;β-catenin;ReactiveOxygenSpecies作⽤通路:Epigenetics;JAK/STATSignaling;ProteinTyrosineKinase/RTK;StemCell/Wnt;NF-κB;Apoptosis;Immunology/Inflammation;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Pentagalloylglucose(Standard)Pentagalloylglucose的分析标准品。本产品⽤于研究及分析应⽤。Pentagalloylglucose(Penta-O-galloyl-β-D-glucose)⼀种⼝服有效的没⾷⼦单宁化合物，也凋亡(apoptosis)和⾃噬(autophagy)诱导剂。Pentagalloylglucose通过GSK3β/β-catenin途径诱导细胞凋亡⾃噬。Pentagalloylglucose具有抗氧化、抗诱变、抗炎、抗惊厥、⼼脏保护、抗过敏、降胆甾醇⾎症和抗肿瘤活性。REFERENCES[1].ZengJ,etal.PentagalloylglucosedisruptsthePALB2-BRCA2interactionandpotentiatestumorsensitivitytoPARPinhibitorandradiotherapy.CancerLett.2022Oct10;546:215851.[2].TongJ,etal.PentagalloylglucosereducesAGE-inducedinflammationbyactivatingNrf2/HO-1andinhibitingtheJAK2/STAT3pathwayinmesangialcells.JPharmacolSci.2021Dec;147(4):305-314.[3].FanCW,etal.PentagalloylglucosesuppressesthegrowthandmigrationofhumannasopharyngealcancercellsviatheGSK3β/β-cateninpathwayinvitroandinvivo.Phytomedicine.2022Jul20;102:154192.[4].ViswanathaGL,etal.Alleviationoftransientglobalischemia/reperfusion-inducedbraininjuryinratswith1,2,3,4,6-penta-O-galloyl-β-d-glucopyranoseisolatedfromMangiferaindica.EurJPharmacol.2013Nov15;720(1-3):286-93.[5].KimYH,etal.1,2,3,4,6-penta-O-galloyl-β-D-glucopyranoseincreasesapopulationofTregulatorycellsandinhibitsIgEproductioninovalbumin-sensitizedmice.IntImmunopharmacol.2015May;26(1):30-6.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3