YPC-22026-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEYPC-22026Cat.No.:HY-120264CASNo.:1964457-41-7分⼦式:C₁₆H₈F₃N₃O₂分⼦量:331.25作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性YPC-22026⼀种锌指蛋⽩143(ZNF143)抑制剂，IC50值为9.0μM。YPC-22026⼀种有效的肿瘤消退诱导剂。YPC-22026表现出抗肿瘤活性。体外研究YPC‐22026(96h)showscytotoxictoHCT116andPC‐3withIC50valuesof0.33μMand0.66μM,respectively[1].YPC‐22026(3μM;24h)inducesG2/MarrestanddecreasesthebindingofZNF143totheSTAFbindingsite[1].CellCycleAnalysis[1]CellLine:HCT116cellsConcentration:3μMIncubationTime:24hResult:InducedG2/Marrest.体内研究YPC‐22026(50-100mg/kg;i.p;ondays1,2,3,8,9,12,and16)significantlyinhibitsthegrowthoftumorsintheHCT116xenograftmodel[1].InthePC‐3xenograftmodel,YPC‐22026(75mg/kg;ip)significantlydecreasesintheintratumoralexpressionlevelsofallZNF143targetgenes,RAD51,PLK1,andSurvivin[1].AnimalModel:Six1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE‐week‐oldmaleBALB/cnudemiceinjectedwithHCT116cells[1]Dosage:50mg/kgand100mg/kgAdministration:i.p;ondays1,2,3,8,9,12,and16(50mg/kg);ondays1,2,3,12,and16(100mg/kg)Result:Significantlyinhibitedthegrowthoftumors.REFERENCES[1].HirotakaHaibara,etal.YPC-21661andYPC-22026,novelsmallmolecules,inhibitZNF143activityinvitroandinvivo.CancerSci.2017May;108(5):1042-1048.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955