阿尔茨海默症英语介绍

Alzheimer’sDisease阿尔茨海默症

阿尔茨海默症英语介绍RonaldWilsonReagan罗纳德·威尔逊·里根第40任（第49-50届）美国总统president“IknowI'monmywaytothetwilight.Iknowthere'salwaysabrightdawnaheadoftheUnitedstates.Thankyou,myfriends.MayGodblessyouforever.”阿尔茨海默症英语介绍briefintroduction01Pathogeny＆Treatment03Clinicalmanifestation02Other04Catalog阿尔茨海默症英语介绍

briefintroduction

1阿尔茨海默症英语介绍What?Alzheimer'sdisease(AD)isaprogressiveneurodegenerativedisorder.临床症状Clinicalsymptom记忆障碍dysmnesia失语aphasia失认agnosia执行功能障碍executivedysfunction痴呆dementiaThediseaseusuallybeginsafterage60,andriskgoesupwithage.阿尔茨海默症英语介绍TwotypesAlzheimer'sdisease(AD)

<65yearsoldseniledementia(SDAT)≥65yearsold阿尔茨海默症英语介绍NameIn1906,ADisnamedbyDr.AloisAlzheimer,aGermandoctor.Dr.Alzheimernoticedchangesinthebraintissueofawomanwhohaddiedofanunusualmentalillness.Hefoundabnormalclumps.ScientistsalsohavefoundotherbrainchangesinpeoplewithAD.Nervecellsdieinareasofthebrainthatarevitaltomemoryandothermentalabilities.阿尔茨海默症英语介绍

Clinicalmanifestation

2阿尔茨海默症英语介绍Clinicalmanifestation

Ⅰ期Ⅱ期Ⅲ期death1-3

years2-10

years8-12yearsMilddementiaModeratedementiaSeveredementiaMorewomenthanmen7:5~4:6Diseaseforupto10-20years阿尔茨海默症英语介绍

DegradationofmemoryandcognitionWilliamUtermohlen的自画像阿尔茨海默症英语介绍Degradationofmemoryandcognition

WilliamUtermohlenisanAmericanartist,in1995hewasdiagnosedwithAlzheimer'sdisease.Sincethen,hehasdecidedtotakeadvantageofthelimitedtimeavailabletoretainmemoryandbetterunderstandhimselfthroughselfportraits.Williaminsistedthe5NewYearpaintingsselfportrait,untilcompletelyforgottenhowtodraw.Fromtheuseofskilleddrawing,darkportrayalofvividfeatures,tothesamecolor,shapedeformation,selfportraitbecamemoreandmoreabstract(picturedabove).阿尔茨海默症英语介绍Degradationofmemoryandcognition

"theeffectsofAlzheimer'sdiseaseontherightparietallobeofthebrainareparticularlysevere,whichdirectlyaffectstheabilityofthebraintovisualizeanddeveloptheabilitytodrawpicturesofthebrain."saidDr.BruceMiller,aneurologist.Hisworkbecamemoreabstract,maybetheparietalfunctiondamaged,causingblindness.Whatkindofchangeshaveoccurredinthebrainsofpatientswithdementia,whichisnotyetfullyunderstoodbytheworld'sacademia.阿尔茨海默症英语介绍

Pathogeny＆Treatment

3阿尔茨海默症英语介绍PathogenesishypothesisofAD阿尔茨海默症英语介绍PathogenyAbnormalamyloidbetacelldepositioninneuronsAbnormalphosphorylationoftauproteinvs阿尔茨海默症英语介绍Betaamyloid(bluecurve)andTauprotein(orangecurve)Researchpaperspublishedinrecent30years阿尔茨海默症英语介绍Treatmentincreasetheconcentrationofacetylcholine(Ach)inthebrainpromotingsurvivalofcholinergicneuronsinthebrainorimprovingtheirnerveconductionfunctionreducingtheproductionorpromotingdegradationofbetaamyloid阿尔茨海默症英语介绍Other4阿尔茨海默症英语介绍StillAliceFilmThefilmtellsthestoryofAliceHowlandinseriouslyADb