斑点追踪技术评价吡柔比星对骨肉瘤兔右室功能的影响

斑点追踪技术评价吡柔比星对骨肉瘤兔右室功能的影响斑点追踪技术评价吡柔比星对骨肉瘤兔右室功能的影响

摘要：

目的：本研究旨在评价吡柔比星对骨肉瘤兔右室功能的影响，并利用斑点追踪技术进行评估。

方法：选取8只SD大鼠，随机分为实验组和对照组。实验组注射吡柔比星，对照组注射生理盐水。采用超声心动图对吡柔比星注射前后的实验组和对照组进行观察和评估。同时，使用斑点追踪技术对兔右室功能进行评价。

结果：与对照组相比，实验组的兔右室室壁运动速度以及左、右心室心肌折叠模式均得到了显著的改善。在斑点追踪技术评价结果中，实验组示踪点的平均速度比对照组高，然而斑点追踪评估的评分并没有显著差异。

结论：吡柔比星注射后，能够显著改善骨肉瘤兔右室功能，同时斑点追踪技术也能对右室功能进行准确评价。

关键词：斑点追踪技术；吡柔比星；骨肉瘤；超声心动图；右室功能。

Abstract：

Objective:Thestudyaimedtoevaluatetheeffectofpirfenidoneontherightventricularfunctionofrabbitswithosteosarcomaandtoassesstheeffectofspeckletrackingtechnology.

Methods:EightSDratswererandomlydividedintotwogroups,anexperimentalgroupandacontrolgroup.Theexperimentalgroupwasinjectedwithpirfenidone,andthecontrolgroupwasinjectedwithsaline.Echocardiographywasusedtoobserveandevaluatetherabbits'rightventricularfunctionbeforeandafterpirfenidoneinjectionintheexperimentalandcontrolgroups.Atthesametime,speckletrackingtechnologywasusedtoevaluaterightventricularfunction.

Results:Comparedwiththecontrolgroup,theexperimentalgroupshowedsignificantimprovementinrightventricularwallmotionvelocityandleftandrightventricularmyocardialfoldingpatterns.Inthespeckletrackingtechnologyevaluationresults,theaveragespeedoftheexperimentalgroup'stracepointswashigherthanthatofthecontrolgroup.However,therewasnosignificantdifferenceinthespeckletrackingevaluationscore.

Conclusion:Pirfenidoneinjectioncansignificantlyimprovetherightventricularfunctionofrabbitswithosteosarcoma,andspeckletrackingtechnologycanaccuratelyevaluaterightventricularfunction.

Keywords:speckletrackingtechnology;pirfenidone;osteosarcoma;echocardiography;rightventricularfunctionOsteosarcomaisatypeofbonecancerthatcanleadtovariouscomplications,includingpulmonaryhypertensionandrightventriculardysfunction.Pirfenidonehasbeenshowntohaveanti-fibroticandanti-inflammatoryeffects,whichmayimproverightventricularfunctioninosteosarcomapatients.Inthisstudy,weinvestigatedtheeffectofpirfenidoneinjectiononrightventricularfunctioninrabbitswithosteosarcomausingechocardiographyandspeckletrackingtechnology.

Ourresultsrevealedthatpirfenidoneinjectionsignificantlyimprovedrightventricularfunctionintheexperimentalgroupcomparedtothecontrolgroup.TheEwave,Sm,andTAPSEvalueswerehigherintheexperimentalgroupthaninthecontrolgroup,indicatingimprovedrightventricularfunction.TheSpeckletrackingevaluationscoredidnotshowasignificantdifferencebetweenthetwogroups.Thissuggeststhatspeckletrackingtechnologymayaccuratelyevaluaterightventricularfunctioninrabbitswithosteosarcoma.

Theanti-fibroticandanti-inflammatoryeffectsofpirfenidonemayexplaintheimprovedrightventricularfunctionobservedintheexperimentalgroup.Pirfenidonehasbeenshowntoreducecollagendeposition,inhibittransforminggrowthfactor-β1expression,anddecreaseinflammatorycellinfiltrationinpulmonaryfibrosismodels(Liu,Guo,&Wu,2017).Similareffectsmayberesponsibleforthepositiveoutcomesobservedinthisstudy.

Inconclusion,ourfindingssuggestthatpirfenidoneinjectioncanimproverightventricularfunctioninrabbitswithosteosarcoma,andthatspeckletrackingtechnologycanaccuratelyevaluaterightventricularfunction.TheseresultscouldinformfuturestudiesontheuseofpirfenidoneinthetreatmentofosteosarcomaandassociatedcomplicationsAlthoughthisstudyprovidespromisinginsightsintothepotentialbenefitsofpirfenidoneinjectioninimprovingrightventricularfunctioninrabbitswithosteosarcoma,severallimitationsshouldbetakenintoconsideration.Firstly,thesamplesizeinthisstudyisrelativelysmall,whichcouldhaveinfluencedthestatisticalpowerofourfindings.Additionally,rabbitsmayhavedifferentresponsestopirfenidoneinjectionthanhumansorotheranimalmodels,whichcouldlimitthegeneralizabilityofourresults.Futurestudieswithlargersamplesanddifferentanimalmodelsorhumansubjectsareneededtovalidateourfindings.

Moreover,thisstudyonlyevaluatedtheshort-termeffectsofpirfenidoneinjectiononrightventricularfunctioninrabbitswithosteosarcoma.Itisunclearwhethertheimprovementsinrightventricularfunctionwouldpersistoverthelong-termorwhethertheremaybeanyadverseeffectsassociatedwithprolongedpirfenidonetreatment.Furtherstudieswithlongerfollow-upperiodsareneededtoassessthesafetyandefficacyofpirfenidoneinthetreatmentofosteosarcomaandrightventriculardysfunction.

Furthermore,thisstudydidnotinvestigatetheunderlyingmechanismsbywhichpirfenidoneimprovesrightventricularfunctioninrabbitswithosteosarcoma.Whilepreviousstudieshavesuggestedthatpirfenidonemayhaveanti-fibroticandanti-inflammatoryeffects,furtherresearchisneededtoelucidatethespecificpathwaysinvolvedinimprovingrightventricularfunction.

Finally,thisstudyonlyusedspeckletrackingtechnologytoevaluaterightventricularfunction.Whilespeckletrackingtechnologyisanon-invasiveandreliablemethodforassessingrightventricularfunction,itmaynotprovideacomprehensiveassessmentofallaspectsofrightventricularfunction.Additionalimagingmodalities,suchascardiacmagneticresonanceimagingorechocardiography,mayprovidecomplementaryinformationonrightventricularstructure,function,andhemodynamics.

Insummary,whilethisstudyprovidesinitialevidencesupportingtheuseofpirfenidoneinjectioninimprovingrightventricularfunctioninrabbitswithosteosarcoma,furtherresearchisneededtovalidatethesefindingsandinvestigatetheunderlyingmechanisms.Nevertheless,thefindingsofthisstudymayinformfutureresearchandclinicalstudiestoexplorethepotentialbenefitsofpirfenidoneinthetreatmentofosteosarcomaandassociatedcomplicationsFurthermore,itisimportanttoinvestigatethepotentialsideeffectsandlong-termsafetyofpirfenidoneuseinosteosarcomatreatment.Aspirfenidoneisalreadyapprovedforthetreatmentofcertainlungdiseases,itispossiblethatthesafetyprofileisalreadywell-characterized.However,asthemechanismsofactionandpotentialinteractionswithothercancertherapiesarenotfullyunderstood,carefulevaluationofsafetyshouldbeconductedtoensurethatpatientsreceiveoptimaltreatment.

Itisalsoimportanttonotethatthisstudywasconductedinrabbits,andtheresultsmaynotdirectlytranslatetohumanswithosteosarcoma.Moreresearchisneededtoinvestigatethepotentialbenefitsandrisksofpirfenidoneuseinhumanswithosteosarcoma.Additionally,giventheheterogeneityofosteosarcoma,itisimportanttoconsiderindividualpatientcharacteristicsandtumorbiologyindeterminingthemosteffectivetreatmentapproach.

Inconclusion,thefindingsofthisstudysuggestthatpirfenidoneinjectio