AT2-receptor-agonist-C21-DataSheet-生命科学试剂-MedChemExpressVIP

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAT2receptoragonistC21Cat.No.:HY-100113CASNo.:477775-14-7分⼦式:C₂₃H₂₉N₃O₄S₂分⼦量:475.62作⽤靶点:AngiotensinReceptor作⽤通路:GPCR/GProtein储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(210.25mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.1025mL10.5126mL21.0252mL5mM0.4205mL2.1025mL4.2050mL10mM0.2103mL1.0513mL2.1025mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.08mg/mL(4.37mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(4.37mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.37mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性AT2receptoragonistC21⼀种类似药物的，选择性angiotensinIIAT2receptor(⾎管紧张素IIAT2受体)激动剂，对AT2受体和AT1受体的Ki值分别为0.4nM和10µM。IC50&TargetKi:0.4nM(AT2)and>10µM(AT1)[1]体内研究AT2receptoragonistC21,withabioavailabilityof20-30%afteroraladministrationandahalf-lifeestimatedto4hinrat,inducesoutgrowthofneuritecells,stimulatesp42/p44mapk,enhancesinvivoduodenalalkalinesecretioninSprague-Dawleyrats,andlowersthemeanarterialbloodpressureinanesthetized,spontaneouslyhypertensiverats[1].户使⽤本产品发表的科研⽂献•ClinSci.2022Jun13;CS20220236.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].WanY,etal.Design,synthesis,andbiologicalevaluationofthefirstselectivenonpeptideAT2receptoragonist.JMedChem.2004Nov18;47(24):5995-6008.[2].SchwengelK,NamsolleckP,LuchtK,etal.AngiotensinAT2-receptorstimulationimprovessurvivalandneurologicaloutcomeafterexperimentalstrokeinmice.JMolMed(Berl).2016;94(8):957-966.[3].FatimaN,PatelS,HussainT.AngiotensinAT2ReceptorisAnti-inflammatoryandReno-ProtectiveinLipopolysaccharideMiceModel:RoleofIL-10.FrontPharmacol.2021;12:600163.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forres