4-Hydroxymephenytoin-D3-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE4-HydroxymephenytoinD3Cat.No.:HY-W008772SCASNo.:1173022-56-4分⼦式:C₁₂H₁₁D₃N₂O₃分⼦量:237.27作⽤靶点:DrugMetabolite作⽤通路:MetabolicEnzyme/Protease储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(421.46mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.2146mL21.0730mL42.1461mL5mM0.8429mL4.2146mL8.4292mL10mM0.4215mL2.1073mL4.2146mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性4-HydroxymephenytoinD34-Hydroxymephenytoin的氘代物。4-Hydroxymephenytoin抗癫痫药mephenytoin的代谢物;mephenytoin为CYP2C19的⼀种配体。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs[1].REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].TanakaM,etal.Simpleandselectiveassayof4-hydroxymephenytoininhumanurineusingsolid-phaseextractionandhigh-performanceliquidchromatographywithelectrochemicaldetectionanditspreliminaryapplicationtophenotypingtest.JChromatogrBBiomedAppl.1996Feb9;676(1):87-94.[3].StewartNA,etal.AUPLC-MS/MSassayofthe"Pittsburghcocktail":sixCYPprobe-drug/metabolitesfromhumanplasmaandurineusingstableisotopedilution.Analyst.2011Feb7;136(3):605-12.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379