Penciclovir-sodium-VSA-671-sodium-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPenciclovirsodiumCat.No.:HY-107739CASNo.:97845-62-0Synonyms:VSA671sodium;BRL39123A;BRL39123D分⼦式:C₁₀H₁₄N₅NaO₃分⼦量:275.24作⽤靶点:HSV作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Penciclovir(VSA671)sodium⼀种有效的选择性抗疹病毒(anti-herpesvirus)剂，对于HSV-1（HFEM），HSV-2（MS）的EC50值分别为0.5,0.8µg/ml。Penciclovirsodium显⽰抗疹病毒活性且⽆细胞毒性。Penciclovirsodium可防⽌⼩⿏死亡[1][2]。IC50&TargetHSV-1HSV-20.5μg/mL(EC50)0.8μg/mL(EC50)体外研究Penciclovirsodium(0-100µg/ml)showsanti-herpesvirusactivitywithEC50sof0.5,0.8,2.4,52,100,1.2,1.6,0.9,>100µg/mlforHSV-1(HFEM),HSV-2(MS),VZV(Ellen),CMV(AD-169),BHV-1(Oxford1964),BHV-2(NewYork1),EHV-1(QuaiHals),FHV-1(B927),SVV,respectively[1].Penciclovirsodium(0-100µg/ml)showsno-toxictouninfectedhumancells[1].CellCytotoxicityAssay[1]CellLine:MRC-5,WISH,Flow4000,Flow12000,RPMI2650,WI-38,WI-38VA13,Hs68,HEp-2,RD,SCC-13,PrimarycellsConcentration:0-100µg/mlIncubationTime:Result:Showedno-toxicwithIC50sof>100,>100,100,>100,60,>100,>100,>100,>100,>100,>100,>100forMRC-5,WISH,Flow4000,Flow12000,RPMI2650,WI-38,WI-381/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEVA13,Hs68,HEp-2,RD,SCC-13,Primarycells,respectively.体内研究Penciclovirsodium(100mg/kg;s.c.;dailyfor5days)preventesmortalityinmouse[2].AnimalModel:Three-week-oldfemaleBalb/cmice[2]Dosage:100mg/kgAdministration:S.c.;dailyfor5daysResult:Reducedvirustitresintherespiratoryorgansofbothw/t-andPR3-infectedmice.户使⽤本产品发表的科研⽂献•MicrochemJ.2021,106587.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].M.R.Boyd,etal.Penciclovir:areviewofitsspectrumofactivity,selectivity,andcross-resistancepattern.AntiviralChemistryandChemotherapy,1993,(1):3-11.[2].delaFuenteR,etal.Theacyclicnucleosideanaloguepenciclovirisapotentinhibitorofequineherpesvirustype1(EHV-1)intissuecultureandinamurinemodel.AntiviralRes.1992May;18(1):77-89.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseo