ZINC05007751-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEZINC05007751Cat.No.:HY-122639CASNo.:591239-68-8分⼦式:C₁₈H₁₂N₂O₃分⼦量:304.3作⽤靶点:Others作⽤通路:Others储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:8.33mg/mL(27.37mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.2862mL16.4312mL32.8623mL5mM0.6572mL3.2862mL6.5725mL10mM0.3286mL1.6431mL3.2862mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性ZINC05007751⼀种有效的NIMA相关激酶NEK6抑制剂，IC50为3.4μM。ZINC05007751对⼀组⼈类癌细胞系显⽰出抗增殖活性，并且在BRCA2突变的巢癌细胞系中显⽰出与铂和紫杉醇的协同效应。ZINC05007751对NEK1和NEK6具有很强的选择性，但对NEK2、NEK7和NEK9没有明显的活性。体外研究ZINC05007751(6μM-190μM;24hours)inhibitsthegrowthofMDA-MB-231,PEO1,NCI-H1299andHCT-15withIC50below100ꢀµM[1].1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEZINC05007751inducesperturbationofPEO1cellcycle[1].ZINC05007751(ovariancancercellsPEO1)showssynergismwithCisplatin,resultinginasignificantreductionofCisplatinIC50from7.9to0.1ꢀꢀµM,withcombinationZINC05007751(44ꢀµM)ꢀ+ꢀCisplatin(10ꢀµM)exhibitingthegreatestsynergisticeffect[1].CellCytotoxicityAssay[1]CellLine:MDA-MB-231,PEO1,NCI-H1299andHCT-15cellsConcentration:6μM-190μMIncubationTime:24ꢀhoursResult:InhibitedthegrowthofMDA-MB-231,PEO1,NCI-H1299andHCT-15.REFERENCES[1].DeDonatoM,etal.IdentificationandantitumoractivityofanovelinhibitoroftheNIMA-relatedkinaseNEK6.SciRep.2018;8(1):16047.Published2018Oct30.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;