Rac-Benpyrine-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemE(Rac)-BenpyrineCat.No.:HY-133807ACASNo.:1333714-43-4分⼦式:C₁₆H₁₆N₆O分⼦量:308.34作⽤靶点:TNFReceptor作⽤通路:Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCOA.溶解性数据体外实验DMSO:12.5mg/mL(40.54mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.2432mL16.2159mL32.4317mL5mM0.6486mL3.2432mL6.4863mL10mM0.3243mL1.6216mL3.2432mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥1.25mg/mL(4.05mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥1.25mg/mL(4.05mM);Clearsolution3.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥1.25mg/mL(4.05mM);Clearsolution1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEBIOLOGICALACTIVITY⽣物活性(Rac)-Benpyrine，Benpyrine的外消旋体，⼀种有效的具有⼝服活性的TNF-α抑制剂。(Rac)-Benpyrine可⽤于TNF-α介导的炎症和⾃⾝免疫性疾病的研究。IC50&TargetTNF-α体外研究(Rac)-Benpyrine(Compound001;5-10μM;24hours)treatmentinhibitstheexpressionlevelofTNF-αdownstreampathwayproteinNF-κBinthenucleusinRAW264.7macrophages[1].体内研究(Rac)-Benpyrine(Compound001;25-50mg/kg;oralgavage;daily;for3weeks;Kunmingmice)treatmentobviouslyreducestheinflammatorycytokinesIFN-γ,IL-1βandIL-6inthebloodserum,andtheanti-inflammatoryfactorIL-10isobviouslyincreased,thefootswellingdegreeofthearthritispartisalsoobviouslysloweddown,andtheweightindexincreasecausedbythearthritisalsohasnoobviousreduction[1].AnimalModel:Kunmingmice(7-8weeks)treatedwithbovinetypeIIcollagenandaCFAcompleteadjuvant[1]Dosage:25mg/kg,50mg/kgAdministration:Oralgavage;daily;for3weeksResult:TheinflammatorycytokinesIFN-γ,IL-1βandIL-6inthebloodserumwereobviouslyreduced,andtheanti-inflammatoryfactorIL-10wasobviouslyincreased.REFERENCES[1].HuaLi,etal.CompoundwithTNF-αinhibitoryactivityandapplication.CN111320630A.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchu