2、46个创新科学问题的小综述2016年-已文献免疫代谢

1、，的代谢并发症的主，的代谢并发症的主 而且还会导致组织损伤，甚至通过破坏修复和重塑或通过产生失语症引起全身性炎症。8, 会提高细胞的糖酵解总量，增强小鼠的炎症反应 15酸激酶 CD8+ （FAO要影响由于对不同解剖位置的Treg细胞发挥组织特异性生理功19- 胞 胞 + 施，在有关肥胖的代谢研究应用到肿瘤中可能会降低肿瘤发生所引起的慢性炎症。靶向 34, 细胞、11. ArsenaultRJ,KogutMH.ImmunometabolismandtheKinome1. ArsenaultRJ,KogutMH.ImmunometabolismandtheKinomePeptideArray:Aa

2、ndToolfortheStudyofGutHealth.FrontVetSci2015;2:2. de Candia P, De Rosa V, Gigantino V, Botti G, Ceriello A, Matarese Immunometabolismofhumanautoimmunediseases:frommetabolitestovesicles. FEBSLett3.YunW,LeeD,ChangS,etal.RoleofCD4CD25FOXP3RegulatoryTCellsinAnnDermatol2010; 22(4): 397-4. Ghoreschi K,Wei

3、gertC, Rcken M. Immunopathogenesis and role of T cellspsoriasis. ClinicsinDermatology2007; 25(6): 574-5. Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune inflammatory diseases. Autoimmunity Reviews 2014; 13(6): 668-6. RosaNetoJC,LiraFS,WT.Immunometabolism:moleculardiseases, and t

4、herapies. Mediators Inflamm2014; 2014: 7. HotamisligilGS.Inflammation,metaflammationandimmunometabolic8. VereeckeL,VieirasilvaS,tT,etal.A20estinalthrough cell-specific activities. Nature Communications 2014; 5(5103): YiZ,StunzLL,7. HotamisligilGS.Inflammation,metaflammationandimmunometabolic8. Veree

5、ckeL,VieirasilvaS,tT,etal.A20estinalthrough cell-specific activities. Nature Communications 2014; 5(5103): YiZ,StunzLL,BishopGA.CD40-mediatedenanceofimmunehomeostasiseemicroenvironment.Diabetes2014;63(8):2751-es.NaturereviewsImmunology2012;12(2):136-reprogramminguponTlymphocyteactivation.Immunity201

6、1;35(6):871-12.MacIverNJ,MichalekRD,RathmellJC.MetabolicregulationofTAnnualreviewofimmunology2013;31:259-13. yreAN,GerrietsVA,NicholsAG,etal.TheglucosetransporterGlut1selectively essential for CD4 T cell activation and effector function. metabolism2014; 20(1): 61-14.Pearce EL, Pearce EJ. Metabolic p

7、athways in immune cell activation quiescence.Immunity2013;38(4):633-15.JacobsSR,HermanCE,MaciverNJ,etal.Glucoseuptakeisactivation and requires CD28-mediated Akt-dependent and independent Journalofimmunology(Baltimore,Md:1950)2008;180(7):4476-16.Palsson-McDermott Eva M, Curtis Anne M, Goel G, et al.

8、Pyruvate KinaseRegulatesHif-1ActivityandIL-1InductionandIsaCriticalDeterminantivatedMacrophages. CellMetabolism2015; 21(1):65-theWarburgEffectin17.Shi LZ, Wang R, Huang G, et al. HIF1dependent glycolytic TheJournalofExperimentalMedicine2011;208(7):1367-18.ZengH,ChiH.MetaboliccontrolofregulatoryTcell

9、developmentandTrendsImmunol2015;36(1):3-19.FeuererM,HerreroL,CipollettaD,etal.Lean,butnotobese,fatisMed2009;15(8):930-20. BurzynD,KuswantoW,KolodinD,etal.Alpopulationofregulatorycellspotentiatesmusclerepair.Cell2013;155(6):1282-21.Samstein R, Josefowicz S,Med2009;15(8):930-20. BurzynD,KuswantoW,Kolo

10、dinD,etal.Alpopulationofregulatorycellspotentiatesmusclerepair.Cell2013;155(6):1282-21.Samstein R, Josefowicz S, Arvey A, Treuting P, Rudensky A. generation of regulatory T cells in placental mammals mitigates maternal-.Cell2012;150(1):29-22.Cipolletta D, Feuerer M, Li A, et al. PPAR- is a major dri

11、ver of eTregcells.Nature2012;accumulationandphenotypeofe23.MichalekRD,GerrietsVA,JacobsSR,etal.Cuttingedge:distinctandoxidativemetabolicprogramsareessentialforeffectorandCD4+Tcellsubsets.Journalofimmunology(Baltimore,Md:1950)2011;3299-24.NaikS,BouladouxN,WilhelmC,etal.Compartmentalizedcontrolofskinb

12、yresidentcommensals.Science2012;337(6098):1115-25.WinerS,ChanY,PaltserG,etal.Normalizationofobesity-tedthroughimmunotherapy.NatMed2009;15(8):921-26.SonHJ,LeeJ.Metforminattenuatesexperimentalautoimmunearthritisreciprocal regulation of Th17/Treg balance and osteoclastogenesis. 2014; 27.HayashiK,Jutabh

13、aP,EndouH,SagaraH,AnzaiN.LAT1isacriticalofessentialaminoacidsforimmunereactionsinactivatedhumanTcells.ofimmunology(Baltimore,Md:1950)2013;191(8):4080-28. Sinclair LV, Rolf J, E, Shi YB, Taylor PM, Cantrell DA. Control amino-acidtransportbyantigenreceptorscoordinatesthemetabolicessentialforTcelldiffe

14、rentiation.Natureimmunology2013;14(5):500-29.NakayaM,XiaoY,ZhouX,etal.InflammatoryTcellresponsesrelyonacidtransporterASCT2ionofglutamineuptakeandmTORC1kinaseImmunity2014; 40(5): 692-30.Sallusto F. Heterogeneity of Human CD4(+) T Cells Against Microbes. reviewofimmunology2016;34:317-31.Ostroukhova M,

15、 Goplen N, Karim MZ, et al. The role of low-level eproductioninairwayinflammationinasthma.Americanjournalofgreviewofimmunology2016;34:317-31.Ostroukhova M, Goplen N, Karim MZ, et al. The role of low-level eproductioninairwayinflammationinasthma.Americanjournalofgcellularandmolecularphysiology2012;30

16、2(3):L300-32.Gerriets VA, Kishton RJ, Nichols AG,et al. Metabolic programming and controlCD4+Tcellsubsetsandinflammation.TheJournalofclinical2015;125(1): 194-33.RosilioC,Ben-Sahrahumanleukemia.Cancerletters2014;346(2):188-anti-diabetic drug34.SongY,DingW,XiaoY,LuKJ.TheProgressofMitophagyandRelatedMechanismsoftheNeurodegenerativeDiseasesandTumor.Neurosciencejournal2015: ,ChawlaA.Metabolicregulationofimmuneresponses.AnnuRev35. 2014;32:609-NewtonR,PriyadharshiniB,TurkaLA.ImmunometabolismofregulatoryTImmunol 2016; 17(6): 618-WardPatrick S,ThompsonCraig B.Metabol