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1、第 第 页雅思阅读考前辅导new weapon to fight cancer1. British scientists are preparing to launch trialsof a radical new way to fight cancer, which killstumours by infecting them with viruses like thecommon cold.2. If successful, virus therapy could eventuallyform a third pillar alongside radiotherapy andchemoth
2、erapy in the standard arsenal againstcancer, while avoiding some of the debilitating side-effects.3. Leonard Seymour, a professor of gene therapy at O*ford University, who has beenworking on the virus therapy with colleagues in London and the US, will lead the trials later thisyear. Cancer Research
3、UK said yesterday that it was e*cited by the potential of Prof Seymourspioneering techniques.4. One of the countrys leading geneticists, Prof Seymour has been working with virusesthat kill cancer cells directly, while avoiding harm to healthy tissue. In principle, youve gotsomething which could be m
4、any times more effective than regular chemotherapy, he said.5. Cancer-killing viruses e*ploit the fact that cancer cells suppress the bodys localimmune system. If a cancer doesnt do that, the immune system wipes it out. If you can geta virus into a tumour, viruses find them a very good place to be b
5、ecause theres no immunesystem to stop them replicating. You can regard it as the cancers Achilles heel.6. Only a small amount of the virus needs to get to the cancer. They replicate, you get amillion copies in each cell and the cell bursts and they infect the tumour cells adjacent andrepeat the proc
6、ess, said Prof Seymour.7. Preliminary research on mice shows that the viruses work well on tumours resistant tostandard cancer drugs. Its an interesting possibility that they may have an advantage inkilling drug-resistant tumours, which could be quite different to anything weve had before.8. Researc
7、hers have known for some time that viruses can kill tumour cells and someaspects of the work have already been published in scientific journals. American scientists havepreviously injected viruses directly into tumours but this technique will not work if the canceris inaccessible or has spread throu
8、ghout the body.9. Prof Seymours innovative solution is to mask the virus from the bodys immunesystem, effectively allowing the viruses to do what chemotherapy drugs do - spread throughthe blood and reach tumours wherever they are. The big hurdle has always been to find a wayto deliver viruses to tum
9、ours via the bloodstream without the bodys immune systemdestroying them on the way.10. What weve done is make chemical modifications to the virus to put a polymer coataround it - its a stealth virus when you inject it, he said.11. After the stealth virus infects the tumour, it replicates, but the co
10、pies do not have thechemical modifications. If they escape from the tumour, the copies will be quickly recognisedand mopped up by the bodys immune system.12. The therapy would be especially useful for secondary cancers, called metastases, whichsometimes spread around the body after the first tumour
11、appears. Theres an awful statisticof patients in the west . with malignant cancers; 75% of them go on to die from metastases,said Prof Seymour.13. Two viruses are likely to be e*amined in the first clinical trials: adenovirus, whichnormally causes a cold-like illness, and vaccinia, which causes cowp
12、o* and is also used in thevaccine against smallpo*. For safety reasons, both will be disabled to make them lesspathogenic in the trial, but Prof Seymour said he eventually hopes to use natural viruses.14. The first trials will use uncoated adenovirus and vaccinia and will be delivered locally tolive
13、r tumours, in order to establish whether the treatment is safe in humans and what dose ofvirus will be needed. Several more years of trials will be needed, eventually also on thepolymer-coated viruses, before the therapy can be considered for use in the NHS. Though theapproach will be e*amined at fi
14、rst for cancers that do not respond to conventionaltreatments, Prof Seymour hopes that one day it might be applied to all cancers.(665 words)Questions 1-6Do the following statements agree with theinformation given in the reading passage? Forquestions 1-6 writeTRUE if the statement agrees with theinf
15、ormationFALSE if the statement contradicts theinformationNOT GIVEN if there is no information on this inthe passage1.Virus therapy, if successful, has an advantage in eliminating side-effects.2.Cancer Research UK is quite hopeful about Professor Seymours work on the virustherapy.3.Virus can kill can
16、cer cells and stop them from growing again.4.Cancers Achilles heel refers to the fact that virus may stay safely in a tumor andreplicate.5.To infect the cancer cells, a good deal of viruses should be injected into the tumor.6.Researches on animals indicate that virus could be used as a new way to tr
17、eat drug-resistant tumors.Question 7-9Based on the reading passage, choose the appropriate letter from A-D for each answer.7.Information about researches on viruses killing tumor cells can be found(A) on TV(B) in magazines(C) on internet(D) in newspapers8.To treat tumors spreading out in body, resea
18、rchers try to(A) change the body immune system(B) inject chemotherapy drugs into bloodstream.(C) increase the amount of injection(D) disguise the viruses on the way to tumors.9.When the chemical modified virus in tumor replicates, the copies(A) will soon escape from the tumor and spread out.(B) will
19、 be wiped out by the bodys immune system.(C) will be immediately recognized by the researchers.(D) will eventually stop the tumor from spreading out.Questions 10-13Complete the sentences below. Choose your answers from the list of words. You can onlyuse each word once.NB There are more words in the
20、list than spaces so you will not use them all.In the first clinical trials, scientists will try to 10 adenovirus and vaccinia, so both theviruses will be less pathogenic than the 11.These uncoated viruses will be applied directlyto certain areas to confirm safety on human beings and the right 12 nee
21、ded. Thee*periments will firstly be 13to the treatment of certain cancersList of Wordsdosage responding smallpo* virusdisable natural ones injectdirected treatment cold-like illnesskill patients e*aminedAnswers Keys:1.答案:FALSE (见第2段:If successful, virustherapy could eventually form a third pillaralo
22、ngside radiotherapy and chemotherapy in thestandard arsenal against cancer, while avoidingsome of the debilitating side-effects. Virus therapy只能避开一些副作用,而不是根除。)2.答案:TRUE (见第3段,特别是最末一句: CancerResearch UK said yesterday that it was e*cited bythe potential of Prof Seymours pioneeringtechniques. )3. 答案:N
23、OT GIVEN (文中没有提到virus可以抑制肿瘤细胞再生长)4. 答案:TRUE (见第5段第3、4句: 这里cancers Achilles heel指 If you can get a virus intoa tumour, viruses find them a very good place to be because theres no immune system tostop them replicating. Achilles heel的意思是唯全都命弱点)5. 答案:FALSE (见第6段第第1句:Only a small amount of the virus need
24、s to get to thecancer.)6. 答案:TRUE (见第7段:Preliminary research on mice shows that the viruses work well ontumours resistant to standard cancer drug. ., which could be quite different to anything wevehad before. )7. 答案:B (见第8段第1、2句:Researchers have known for some time that viruses can killtumour cells and some aspects of the work have already been published in scientific journals.Journal意思是日报、期刊、杂志)8. 答案:D (见第9段第1句:Prof Seymours innovative solution is to mask the virus fromthe bodys immune system, . mask的意思是掩盖、隐藏、伪装, 在这里和 disguise同义。)9. 答案:B (见第11段第2句: If they escape from the tumour,
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