Salvianolic-acid-A - MMP - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESalvianolic acid ACat. No.: HY-N0318CAS No.: 96574-01-5分式: CHO分量: 494.45作靶点: MMP作通路: Metabolic Enzyme/Protease储存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性数据体外实验 DMSO : 125 mg/mL

2、(252.81 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.0224 mL 10.1122 mL 20.2245 mL5 mM 0.4045 mL 2.0224 mL 4.0449 mL10 mM 0.2022 mL 1.0112 mL 2.0224 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验 请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，

3、当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (4.39 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (4.39 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules

4、 您边的抑制剂师www.MedChemE物活性 Salvianolic acid A 可通过抑制质属钛酶 9 (MMP-9) 和抗炎作来保护脑屏障。IC50 & Target MMP-9体内研究 A significant beneficial effect of Salvianolic acid A (SAA) is observed in the Salvianolic acid A treatmentgroups. Salvianolic acid A (20 mg/kg) could significantly prolonged the retention time of rats

5、on the plate. Whilecompared with sham operation group, the brain water content in model group significantly increases, which isattenuated significantly by Salvianolic acid A (10 and 20 mg/kg). Compared with the model group, Salvianolicacid A (5, 10, and 20 mg/kg) could maintain the normal structures

6、 of neurons and increase neurons number. Itis also found that Salvianolic acid A (20 mg/kg) could significantly reduce I/R induced MMP-9 upregulation.While the MMP-2 expression is not significantly affected by Salvianolic acid A. Tissue inhibitors ofmetalloproteinases (TIMPs) could inhibit the activ

7、ity of MMPs through high affinity binding to MMPs catalyticdomain 1.REFERENCES1. Zhang W, et al. Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrierthrough MMP-9 inhibition and anti-inflammation. Chin J Nat Med. 2018 Mar;16(3):184-193.McePdfHeightCaution: Product has not been fully validated for medical applications.For research u