L-Arginine-hydrochloride-S-plus-Arginine-hydrochloride-DataSheet-生命科学试剂-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEL-Arginine hydrochlorideCat. No.: HY-N0455ACAS No.: 1119-34-2Synonyms: (S)-(+)-Arginine hydrochloride分式: CHClNO分量: 210.66作靶点: NO Synthase作通路: Immunology/Inflammation储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C

2、1 month溶解性数据体外实验 H2O : 100 mg/mL (474.70 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 4.7470 mL 23.7349 mL 47.4699 mL5 mM 0.9494 mL 4.7470 mL 9.4940 mL10 mM 0.4747 mL 2.3735 mL 4.7470 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活

3、性 L-Arginine hydrochloride (S)-(+)-Arginine hydrochloride) 为合成氧化氮的氮供体，管扩张剂。体外研究Arginine is an -amino acid. The L-form is one of the 20 most common natural amino acids. At the level ofmolecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA,and AGG, are the

4、 triplets of nucleotide bases or codons that code for arginine during protein synthesis. In1/2 Master of Small Molecules 您边的抑制剂师www.MedChemEmammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on thedevelopmental stage and health status of the individua

5、l.L-Arginine is associated with a decrease in cardiacindex while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours isachieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine(450 mg/kg during a 15-minute period) a

6、mplifies and sustains the hyperemia (38%) and increases absolutebrain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for14 days) in SV-129 mice.REFERENCES1. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.2. Bakker J, et a

7、l. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusionfor up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 14

8、4-002). Crit Care Med. 2004 Jan;32(1):1-12.3. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statintreatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.McePdfHeightCaution: Product has not been fully validated for medical applications.Fo