Antibiotic-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/antibiotic.html AntibioticAntibioticAntibiotics are a class of secondary metabolites produced from microorganisms, animals or plants. Some of them exhibitanti-bacterial, anti-fungal, anthelmintic, anti-tumor or immunosuppressive activities with a wealth of stru

2、ctural classes such as -lactams, macrolide and polyether. As major sources of antibiotics, streptomycetes, penicillium and marine organisms produce awide variety of commercially important polyketide compounds including the well-known macrolide, polyene and polyetherantibiotics with wide range of act

3、ivities. Antibiotics such as penicillin, cephalosporin, streptomycin, and tetracycline can be used inthe treatment of human and veterinary diseases. However, antibiotic resistance is also a growing threat to global public health.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/antibiotic.html An

4、tibiotic HYPERLINK https:/www.MedChemE/Targets/antibiotic.html HYPERLINK https:/www.MedChemE/Targets/antibiotic.html Inhibitors HYPERLINK https:/www.MedChemE/6r-7s-cefminox-sodium-heptahydrate.html (6R,7S)-Cefminox HYPERLINK https:/www.MedChemE/6r-7s-cefminox-sodium-heptahydrate.html HYPERLINK https

5、:/www.MedChemE/6r-7s-cefminox-sodium-heptahydrate.html sodium HYPERLINK https:/www.MedChemE/6r-7s-cefminox-sodium-heptahydrate.html HYPERLINK https:/www.MedChemE/6r-7s-cefminox-sodium-heptahydrate.html heptahydrateCat. No.: HY-107330 HYPERLINK https:/www.MedChemE/r-fangchinoline.html (R)-Fangchinoli

6、ne(Thalrugosine; Thaligine) Cat. No.: HY-N1372(6R,7S)-Cefminox sodium heptahydrate is an isomerof Cefminox sodium heptahydrate. Cefminox sodiumheptahydrate is a -lactam cephalosporinantibiotic, which exhibits a broad spectrum ofantibacterial activity.(R)-Fangchinoline (Thalrugosine), a alkaloids fro

7、mgenus Stephaniaexhibits antimicrobial andhypotensive activity.Purity: 98.19%Clinical Data: No Development ReportedSize: 100 mgPurity: 99.83%Clinical Data: No Development ReportedSize: 5 mg, 10 mg HYPERLINK https:/www.MedChemE/r-ofloxacin-d3.html (R)-Ofloxacin-d3 HYPERLINK https:/www.MedChemE/r-oflo

8、xacin-d3.html HYPERLINK https:/www.MedChemE/s-1-4-hydroxyphenyl-ethane-1-2-diol.html (S)-1-(4-Hydroxyphenyl)ethane-1,2-diolCat. No.: HY-B0330DS Cat. No.: HY-W087444A(R)-Ofloxacin-d3 is the deuterium labeled(R)-Ofloxacin. (R)-Ofloxacin (Dextrofloxacin) isan antibiotic useful for the treatment of a nu

9、mberof bacterial infections. Antibacterial activity.(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol is anactive constituent of the aerial parts of Angelicasinensis. (S)-1-(4-Hydroxyphenyl)ethane-1,2-diolsignificantly inhibits the growth of Aeromonashydrophila. Anticoagulative and antibioticactivities.Purity:

10、 98%Clinical Data: No Development ReportedSize: 2.5 mg, 25 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/s-ofloxacin-d3.html (S)-Ofloxacin-d3Cat. No.: HY-B0330S1 HYPERLINK https:/www.MedChemE/_S_-Tedizolid.html (S)-Tedizolid(S)-TR 700; (S)-DA 7157)

11、 Cat. No.: HY-14855A(S)-Ofloxacin-d3 is the deuterium labeledLevofloxacin. Levofloxacin, a syntheticfluoroquinolone, is an antibacterial agent thatinhibits the supercoiling activity of bacterialDNA gyrase, halting DNA replication.(S)-Tedizolid is the S-enantiomer of Tedizolid.Tedizolid is a novel ox

12、azolidinone with activityagainst Gram-positive pathogens. (S)-Tedizolid isthe less active isomer.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 95.56%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg HYPERLINK https:/www.MedChemE/1-deoxynojirimycin-

13、hydrochloride.html 1-Deoxynojirimycin HYPERLINK https:/www.MedChemE/1-deoxynojirimycin-hydrochloride.html HYPERLINK https:/www.MedChemE/1-deoxynojirimycin-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/1-deoxynojirimycin-hydrochloride.html HYPERLINK https:/www.MedChemE/10-Undecenoic-

14、acid.html 10-Undecenoic HYPERLINK https:/www.MedChemE/10-Undecenoic-acid.html HYPERLINK https:/www.MedChemE/10-Undecenoic-acid.html acid(Duvoglustat hydrochloride) Cat. No.: HY-14860A (Undecylenic acid) Cat. No.: HY-B09141-Deoxynojirimycin hydrochloride (Duvoglustathydrochloride) is a potent and ora

15、lly active-glucosidase inhibitor. 1-Deoxynojirimycinhydrochloride suppresses postprandial bloodglucose and is widely used for diabetes mellitus.10-Undecenoic acid was used as a starting reagentin the syntheses of Pheromone (11Z)-hexadecenal.Purity: 98%Clinical Data: Phase 2Size: 5 mg, 10 mg, 25 mgPu

16、rity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg HYPERLINK https:/www.MedChemE/10-Undecenoic-acid-zinc-salt.html 10-Undecenoic HYPERLINK https:/www.MedChemE/10-Undecenoic-acid-zinc-salt.html HYPERLINK https:/www.MedChemE/10-Undecenoic-acid-zinc-salt.html acid HYPERLINK https:/www.MedChemE/

17、10-Undecenoic-acid-zinc-salt.html HYPERLINK https:/www.MedChemE/10-Undecenoic-acid-zinc-salt.html zinc HYPERLINK https:/www.MedChemE/10-Undecenoic-acid-zinc-salt.html HYPERLINK https:/www.MedChemE/10-Undecenoic-acid-zinc-salt.html salt HYPERLINK https:/www.MedChemE/10-Undecenoic-acid-zinc-salt.html

18、HYPERLINK https:/www.MedChemE/1233b.html 1233B(Zinc undecylenate) Cat. No.: HY-B0914ACat. No.: HY-12570610-Undecenoic acid zinc salt is a natural orsynthetic fungistatic fatty acid, is usedtopically in creams against fungal infections,eczemas, ringworm, and other cutaneous conditions.The zinc provid

19、es an astringent action.1233B is a secondary metabolite from filamentousfungus, Fusarium sp. RK97-94.Purity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https

20、:/www.MedChemE/15-acetoxyscirpenol.html 15-Acetoxyscirpenol HYPERLINK https:/www.MedChemE/15-acetoxyscirpenol.html HYPERLINK https:/www.MedChemE/2-3-dideoxy-5-iodocytidine.html 2,3-Dideoxy-5-iodocytidineCat. No.: HY-N6681 Cat. No.: HY-W04847815-acetoxyscirpenol, one of acetoxyscirpenolmoiety mycotox

21、ins (ASMs), strongly inducesapoptosis and inhibits Jurkat T cell growth in adose-dependent manner by activating othercaspases independent of caspase-3.2,3-Dideoxy-5-iodocytidine is used for genesequencing can be used as an antibiotic.2,3-Dideoxy-5-iodocytidine is particulareffective against Mycobact

22、erium.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/2,2_acute_:5_acute_,2_acute_acute_-Terthiophene.html 2,2:5,2-Terthiophene(-Terthiophene; -Terthienyl; Trithiophene) Cat. No.: HY-N204

23、8 HYPERLINK https:/www.MedChemE/2-4-diacetylphloroglucinol.html 2,4-DiacetylphloroglucinolCat. No.: HY-1184482,2:5,2-Terthiophene (-Terthiophene) is anoligomer of the heterocycle thiophene.2,2:5,2-Terthiophene has been employed asbuilding block for the organic semi-conductorpolythiophene.2,4-Diacety

24、lphloroglucinol, produced by someisolates of the beneficial bacterium Pseudomonasfluorescens, is a potent antibiotic.2,4-Diacetylphloroglucinol is active againstnumerous organisms, including plants, fungi,viruses, bacteria, and nematodes.Purity: 99.59%Clinical Data: No Development ReportedSize: 10 m

25、M 1 mL, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/2-Phenylethanol.html 2-Phenylethanol(Phenylethyl alcohol; Phenethyl alcohol; Benzyl carbinol) Cat. No.: HY-B1290 HYPERLINK https:/www.MedChemE/4-aminosalicylic-acid.html 4-Aminosalicylic HYP

26、ERLINK https:/www.MedChemE/4-aminosalicylic-acid.html HYPERLINK https:/www.MedChemE/4-aminosalicylic-acid.html acidCat. No.: HY-I04472-Phenylethanol (Phenethyl alcohol), extractedfrom rose, carnation, hyacinth, Aleppo pine,orange blossom and other organisms, is acolourless liquid. It has a pleasant

27、floral odorand also an autoantibiotic produced by the fungusCandida albicans.4-Aminosalicylic acid (ASA) is an orally activeantibiotic and has the potential to treattuberculosis.Purity: 99.64%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 500 mg, 1 gPurity: 97.32%Clinical Data: LaunchedSize

28、: 500 mg HYPERLINK https:/www.MedChemE/4-bromo-a23187.html 4-Bromo HYPERLINK https:/www.MedChemE/4-bromo-a23187.html HYPERLINK https:/www.MedChemE/4-bromo-a23187.html A23187 HYPERLINK https:/www.MedChemE/4-bromo-a23187.html HYPERLINK https:/www.MedChemE/4-epianhydrotetracycline-hydrochloride.html 4-

29、Epianhydrotetracycline HYPERLINK https:/www.MedChemE/4-epianhydrotetracycline-hydrochloride.html HYPERLINK https:/www.MedChemE/4-epianhydrotetracycline-hydrochloride.html hydrochlorideCat. No.: HY-N6694 Cat. No.: HY-1364394-Bromo A23187 is a halogenated analog of thehighly selective calcium ionophor

30、e A-23187.4-Bromo A23187a calcium modulator, inducesapoptosis in different cells, including HL-60cells.Purity: 99.0%Clinical Data: No Development ReportedSize: 1 mg4-Epianhydrotetracycline hydrochloride is adegradation product of the antibioticTetracycline. 4-Epianhydrotetracyclinehydrochloride is a

31、ctive against Pseudomonas,Agrobacterium, Moraxella, Bacillus, and E.coli (MIC s = 0.75-16 mg/L).50Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/4-epitetracycline-hydrochloride.html 4-Epitetracycline HYPERLINK https:/www.MedChemE/4-epitetracycline-hyd

32、rochloride.html HYPERLINK https:/www.MedChemE/4-epitetracycline-hydrochloride.html hydrochloride HYPERLINK https:/www.MedChemE/4-epitetracycline-hydrochloride.html HYPERLINK https:/www.MedChemE/5-Azacytidine.html 5-AzacytidineCat. No.: HY-136443(Azacitidine; 5-AzaC; Ladakamycin) Cat. No.: HY-105864-

33、Epitetracycline hydrochloride is an epimer ofthe antibiotic Tetracycline. Epimers ofTetracycline form without catalysis and areconsidered degradation products.5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin)is a nucleoside analogue of cytidine thatspecifically inhibits DNA methylation.Purity: 98%Cli

34、nical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.40%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg, 200 mg, 500 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/5-hydroxypyrazine-2-carboxylic-acid.html 5-Hydroxypyrazine-2-Carboxylic HYPERLINK https:/www.MedChemE/5-hydroxypyrazine-2-carbo

35、xylic-acid.html HYPERLINK https:/www.MedChemE/5-hydroxypyrazine-2-carboxylic-acid.html AcidCat. No.: HY-76210 HYPERLINK https:/www.MedChemE/5Z-7-Oxozeaenol.html 5Z-7-Oxozeaenol(FR148083; L783279; LL-Z 1640-2) Cat. No.: HY-126865-Hydroxypyrazine-2-Carboxylic Acid, a metaboliteof anti-tuberculosis dru

36、g pyrazinamide (PZA).5Z-7-Oxozeaenol is a natural anti-protozoancompound from fungal origin, acting as a potentirreversible and selective inhibitor of TAK1 andVEGF-R2, with IC s of 8 nM and 52 nM,50respectively.Purity: 99.99%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 500 mgPurity: 99.50

37、%Clinical Data: No Development ReportedSize: 1 mg HYPERLINK https:/www.MedChemE/6-diazo-5-oxo-l-nor-leucine.html 6-Diazo-5-oxo-L-nor-Leucine(L-6-Diazo-5-oxonorleucine; DON) Cat. No.: HY-108357 HYPERLINK https:/www.MedChemE/7-Aminoactinomycin_D.html 7-Aminoactinomycin HYPERLINK https:/www.MedChemE/7-

38、Aminoactinomycin_D.html HYPERLINK https:/www.MedChemE/7-Aminoactinomycin_D.html D(7-AAD) Cat. No.: HY-D1020L-6-Diazo-5-oxonorleucine(L-6-Diazo-5-oxonorleucine) is a glutaminasesantagonist with a K of 6 M.iL-6-Diazo-5-oxonorleucine exhibits antibacterial,antiviral and anticancer properties.7-Aminoact

39、inomycin D (7-AAD) a fluorescent DNAstain, is a potent RNA polymerase inhibitor.7-Aminoactinomycin D selectively binds to GCregions of the DNA. 7-Aminoactinomycin D also hasantibacterial effects.Purity: 99.92%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mgPurity: 97.42%Clinical Da

40、ta: No Development ReportedSize: 1 mg HYPERLINK https:/www.MedChemE/7-Aminocephalosporanic-acid.html 7-Aminocephalosporanic HYPERLINK https:/www.MedChemE/7-Aminocephalosporanic-acid.html HYPERLINK https:/www.MedChemE/7-Aminocephalosporanic-acid.html acid(7-ACA) Cat. No.: HY-B1434 HYPERLINK https:/ww

41、w.MedChemE/8-Hydroxyquinoline.html 8-Hydroxyquinoline(8-Quinolinol) Cat. No.: HY-B10057-Aminocephalosporanic acid is the core chemicalstructure for the synthesis of cephalosporinantibiotics, is a potent -lactamase inhibitor.8-Hydroxyquinoline (8-Hydroxyquinoline) is amonoprotic bidentate chelating a

42、gent, exhibitsantiseptic, disinfectant, and pesticideproperties, functioning as a transcriptioninhibitor.Purity: 98.0%Clinical Data: No Development ReportedSize: 100 mgPurity: 99.99%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 100 mg HYPERLINK https:/www.MedChemE/8-hydroxyquinoline-hemisu

43、lfate.html 8-Hydroxyquinoline HYPERLINK https:/www.MedChemE/8-hydroxyquinoline-hemisulfate.html HYPERLINK https:/www.MedChemE/8-hydroxyquinoline-hemisulfate.html hemisulfate HYPERLINK https:/www.MedChemE/8-hydroxyquinoline-hemisulfate.html HYPERLINK https:/www.MedChemE/Acetylazide.html Acetylazide(8

44、-Quinolinol hemisulfate) Cat. No.: HY-W012037 (Acetylkelfizina; Acetylsulfamethoxypyrazine; FI6073) Cat. No.: HY-1015758-Hydroxyquinoline hemisulfate (8-Quinolinolhemisulfate) is a monoprotic bidentate chelatingagent, exhibits antiseptic, disinfectant, andpesticide properties, functioning as atransc

45、ription inhibitor.Acetylazide is a synthetic broad-spectrumbacteriostatic antibiotic.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Acetylspiramycin.html Acetylspiramycin HYPERLINK https

46、:/www.MedChemE/Acetylspiramycin.html HYPERLINK https:/www.MedChemE/actinonin.html Actinonin(Spiramycin B; Spiramycin II; Foromacidin B) Cat. No.: HY-B1916 (-)-Actinonin) Cat. No.: HY-113952Acetylspiramycin (Spiramycin B; Spiramycin II;Foromacidin B) is a potent and orally activemacrolide antibiotic

47、produced by variousStreptomyces species, an acetylated derivativeof Spiramycin (HY-100593).Actinonin (-)-Actinonin) is a naturally occurringantibacterial agent produced by Actinomyces.Actinonin inhibits aminopeptidase M,aminopeptidase N and leucine aminopeptidase.Purity: 98%Clinical Data: LaunchedSi

48、ze: 10 mM 1 mL, 200 mgPurity: 99.30%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/Acyclovir.html Acyclovir(Aciclovir; Acycloguanosine) Cat. No.: HY-17422 HYPERLINK http

49、s:/www.MedChemE/acyclovir-d4.html Acyclovir-d4(Aciclovir-d4; Acycloguanosine-d4) Cat. No.: HY-17422S1Acyclovir (Aciclovir) is a guanosine analogue andan orally active antiviral agent. Acyclovirinhibits HSV-1 (IC of 0.85 M), ( of50 HSV-2 IC500.86 M) and varicella-zoster virus.Acyclovir-d4 (Aciclovir-

50、d4) is the deuteriumlabeled Acyclovir. Acyclovir (Aciclovir) is aguanosine analogue and an orally active antiviralagent. Acyclovir inhibits HSV-1 (IC of 0.8550M), HSV-2 (IC of 0.86 M) andvirus.50 varicella-zosterPurity: 99.34%Clinical Data: LaunchedSize: 10 mM 1 mL, 50 mg, 100 mg, 500 mgPurity: 98%C

51、linical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/acyclovir-d4-l-leucinate.html Acyclovir-d4 HYPERLINK https:/www.MedChemE/acyclovir-d4-l-leucinate.html HYPERLINK https:/www.MedChemE/acyclovir-d4-l-leucinate.html L-Leucinate HYPERLINK https:/www.MedChemE/acyclovir-d

52、4-l-leucinate.html HYPERLINK https:/www.MedChemE/aflatoxin-b2.html Aflatoxin HYPERLINK https:/www.MedChemE/aflatoxin-b2.html HYPERLINK https:/www.MedChemE/aflatoxin-b2.html B2Cat. No.: HY-17422S Cat. No.: HY-N6696Acyclovir-d4 L-Leucinate is the deuterium labeledAcyclovir. Acyclovir (Aciclovir) is a

53、guanosineanalogue and an orally active antiviral agent.Acyclovir inhibits HSV-1 (IC of 0.85 M),50HSV-2 IC( 50 of 0.86 M) and varicella-zoster virus.Aflatoxin B2 is a major naturally producedaflatoxin. Aflatoxin B2 is a mycotoxin produced bythe fungi Aspergillus flavus and Aspergillusparasiticus.Puri

54、ty: 98%Clinical Data: No Development ReportedSize: 1 mg, 10 mgPurity: 99.41%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/aflatoxin-g1.html Aflatoxin HYPERLINK https:/www.MedChemE/aflatoxin-g1.html HYPERLINK https:/www.MedChemE/aflatoxin-g1.html G1 HYPERLINK ht

55、tps:/www.MedChemE/aflatoxin-g1.html HYPERLINK https:/www.MedChemE/aflatoxin-g2.html Aflatoxin HYPERLINK https:/www.MedChemE/aflatoxin-g2.html HYPERLINK https:/www.MedChemE/aflatoxin-g2.html G2Cat. No.: HY-N6697 Cat. No.: HY-N6698Aflatoxin G1 is one type of aflatoxins occuring innature. It is produce

56、d by molds, such asAspergillus flavus and Aspergillus parasiticus.Aflatoxin G2 is a major naturally producedaflatoxin. Aflatoxin G2 is a mycotoxin produced bythe fungi Aspergillus flavus and Aspergillusparasiticus.Purity: 99.94%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.0%Clini

57、cal Data: No Development ReportedSize: 1 mg HYPERLINK https:/www.MedChemE/AFN-1252.html AFN-1252 HYPERLINK https:/www.MedChemE/AFN-1252.html HYPERLINK https:/www.MedChemE/agrochelin.html Agrochelin(API-1252; Debio 1452) Cat. No.: HY-16911Cat. No.: HY-130995AFN-1252(Debio 1452) is a potent inhibitor

58、ofenoyl-acyl carrier protein reductase (FabI),inhibited all clinical isolates of Staphylococcusaureus and Staphylococcus epidermidis atconcentrations of 0.12 g/ml.Agrochelin, an alkaloid cytotoxic antibiotic, isproduced by the fermentation of a marineAgrobacterium sp. Agrochelin has cytotoxicactivit

59、y in tumor cell lines.Purity: 99.13%Clinical Data: Phase 2Size: 10 mM 1 mL, 5 mg, 10 mg, 50 mgPurity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg HYPERLINK https:/www.MedChemE/alafosfalin.html Alafosfalin HYPERLINK https:/www.MedChemE/alafosfalin.html HYPERLINK https:/www.MedCh

60、emE/alamethicin.html AlamethicinCat. No.: HY-119881 Cat. No.: HY-N6708Alafosfalin is an inhibitor of cell wallbiosynthesis. Alafosfalin is a phosphonodipeptidewith antibacterial properties.Alamethicin, isolated from Trichoderma viride,is a channel-forming peptide antibiotic andinduces voltage-gated