IMR-1 - Notch 抑制剂 - 生命科学试剂 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIMR-1Cat. No.: HY-100431CAS No.: 310456-65-6分式: CHNOS分量: 353.41作靶点: Notch作通路: Neuronal Signaling; Stem Cell/Wnt储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (282.96 mM)H2O : 40%

2、 PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.07 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.07 mM); Suspended solution; Need ultrasonic1/2 Master of Small Molecules 您边的抑制剂师www.MedChemE3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL

3、(7.07 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 IMR-1类新的 Notch 抑制剂， IC50 为 26 M。IMR-1 阻 Maml1 募集到染质上的 Notch 三元复合体 (NTC)，抑制 Notch 靶 因转录并显 抑制患者衍的肿瘤异种移植模型中的肿瘤长。IC50 & Target IC50: 26 nM (Notch) 1体内研究 IMR-1 (i.p.; 15mg/kg; for 28 days) inhibits Notch-dependent tumor growth in patient-derived xenograft m

4、odels1.Animal Model: Nude mouses with adenocarcinoma xenograft 1Dosage: 15mg/kgAdministration: I.p.; for 28 daysResult: Blocks tumor establishment.REFERENCES1. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. CancerRes. 2016 Jun 15;76(12):3593-603.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: