Belizatinib-TSR-011-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBelizatinibCat. No.: HY-17603CAS No.: 1357920-84-3Synonyms: TSR-011分式: CHFNO分量: 577.73作靶点: ALK; Trk Receptor作通路: Protein Tyrosine Kinase/RTK; Neuronal Signaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 mon

2、th溶解性数据体外实验 DMSO : 300 mg/mL (519.27 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 1.7309 mL 8.6546 mL 17.3091 mL5 mM 0.3462 mL 1.7309 mL 3.4618 mL10 mM 0.1731 mL 0.8655 mL 1.7309 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Bel

3、izatinib种有效的，可服的ALK 和 TRKA、TRKB、TRKC 双重 抑制剂，对野型重 组 ALK 的 IC50 值为0.7 nM。IC50 & Target IC50: 0.7nM (ALK) 11/2 Master of Small Molecules 您边的抑制剂师www.MedChemE体外研究 TSR-011 has antitumour activity in the clinical trials.体内研究 TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse

4、 models 1.户使本产品发表的科研献 J Pharm Biomed Anal. 2019 Apr 6;171:132-147.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Sullivan I, et al. ALK inhibitors in non-small cell lung cancer: the latest evidence and developments. Ther Adv Med Oncol. 2016Jan;8(1):32-47.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 0