女生于196 4年1998年获得博士学位教授；无机化学专业博 …

1、刘杰，女，教授，博士生导师。联系电话Email：tliuliu；cesliuj【学习及工作简历】1995-1998，东北师范大学化学院；博士生，师从著名多酸研究专家王恩波教授；1998-2000，中山大学化学与化学工程学院，博士后，师从计亮年院士；2000.9-2007.11，中山大学化学与化学工程学院，副教授，硕士生导师，博士生导师；2007.12- 暨南大学生命科学技术学院 化学系，教授，博士生导师。研究生招生培养专业：无机化学（生物无机化学方向）；应用化学（化学生物学方向）；生物化学与分子生物学。主持和参加多项国家自然科学基金等项目，培养了硕士生10名，博士生5

2、名。【研究兴趣与主要方向】主要从事生物无机化学、药物化学、分子生物学、细胞生物学等交叉学科的研究；1. 小分子配合物的生物活性及其调控细胞信号转导途径的功能。2. 纳米微球药物的制备、缓释控制及其靶向功能的研究与应用。3. 具有抗肿瘤、抗病毒（HIV、HSV、流感病毒等）、抗菌活性的化学新药研制与开发。【主持科研项目】(1) 国家自然科学基金项目：钌配合物诱导肺癌A549细胞的凋亡及对细胞端粒酶活性的影响；(2) 广东省科技攻关项目：钌配合物(cct-Ru-biim)和(m-Ru-biim)作为抗肿瘤新药的临床前研究；(3) 广东省科技攻关项目：具有抑制（人）禽流感病毒活性的药物设计合成及药效

3、学研究；(4) 北京大学天然药物及仿生药物国家重点实验室开放基金；钌配合物抗肿瘤活性及诱导肿瘤细胞凋亡的研究；(5) 广州市科技攻关项目：具有抗肿瘤活性的新型手性纳米药物的研究；(6) 广东省科技攻关项目：手性纳米药物的合成及其抗肿瘤活性；(7) 广东省自然科学基金项目：抑制流感病毒诱导宿主细胞凋亡的纳米手性药物的合成；(8) 广东省博士后基金卟啉配合物的合成、抗病毒活性及作用机制的研究。作为主要参加人，参加国家自然科学基金重点项目、国家自然科学基金杰出青年基金项目等多项课题研究。【科研论文】(*为通讯作者)作为通讯作者在包括Inorg. Chem.， Dalton. Trans.， J. I

4、norg. Biochem.， Eur. J. Med.Chem.， Antiviral Res.，等期刊发表SCI收录论文50篇。担任Inorg. Chem.、J. Inorg. Biochem.、Antiviral Res和Inorg. Chim. Acta国际知名的学术刊物审稿人。代表论文：(1) Caiping Tan, Jie Liu*, Hong Li, Wenjie Zheng, Shuo Shi, Lanmei Chen, Liangnian Ji*. Dierences in structure, physiological stability, electrochemist

5、ry, cytotoxicity, DNA and protein binding properties between two Ru(III) complexes.J.Inorg. Biochem.2008, 102,347-358. （IF：2.654）(2) Shuo Shi, Jie Liu*, Tianming Yao, Xiaoting Geng, Lingfeng Jiang, Qingyuan Yang, Lin Cheng, and Liangnian Ji*, Promote the Formation and Stabilization of G-Quadruplex b

6、y Dinuclear RuII Complex Ru2(obip)L4, Inorg.Chem.(IF:3.911), ic-2007-021209.(accepted).(3) Jie Liu*, Ya-Nan Liu, Shuo Shi, Wen-Jie Mei, Cai-Ping Tan, Lan-Mei Chen, Wen-Jie Zheng* Liang-Nian Ji. In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth boro

7、tungstate heteropoly blues. Eur. J.Med.Chem. in press, (校对稿) （IF：2.187）(4) Jie Liu*, WenJie Zheng*， Shuo Shi, Caiping Tan, Jincan Chen, Kangcheng Zheng, Liangnian Ji. Synthesis, Antitumor Activity and Structure-Activity Relationships of a Series of Ru(II) Complexes.J.Inorg. Biochem.2008, 102, 193-20

8、2.（IF：2.654）(5) LanMei Chen, Jie Liu,*Jin-Can Chen, Cai-Ping Tan, Shuo Shi,Kang-Cheng Zheng, Ji Liang-Nian*Synthesis,characterization,DNA-binding and spectralpropertiesof complexes Ru(L)4(dppz)2+(L= Im and MeIm) J.Inorg. Biochem. 2008,102,330-341（IF：2.654）(6) Lan-Mei Chen, Jie Liu,*Jin-Can Chen, Cai

9、-Ping Tan, Shuo Shi,Kang-Cheng Zheng, iang-Nian Ji* Experimental and theoretical studies on the DNA-binding and spectral properties of water-soluble complex Ru(MeIm)4(dpq)2+. J Mol. Structure. in press, (校对稿)(7) Shi Shuo, Tan Caiping, Liu Jie, Ji, Liangnian*. Conformation conversion and stabilizatio

10、n of G-Quadruplex by dinuclear rull complex (bpy)2Ru(obip)Ru(bpy)24+J.Biomolecular.Structure, 2007,24 (6): 706(8) Wen Jie Mei,* XinYu Wei, Jie Liu, Wei Gang Lu. Synthesis, characterization and RnA-binding properties of a novel ruthenium complex coordinated by 5-pyridine-10,15,20-triphenylporphyin.Tr

11、ans. Metal. Chem. 2007, 32, 685-688.(9) Shuo Shi , Jie Liu*, Jun Li, Kang-Cheng Zheng, Xiao-Mei Huang, Cai-Ping Tan, Lan-Mei Chen, Liang-Nian Ji*. Synthesis, characterization and DNA-binding of novel chiral complexes D- and L-Ru(bpy)2L2+ (L = o-mopip and p-mopip). J. Inorg. Biochem. 2006, 100(3)：385

12、-395. （IF：2.654）(10) Shuo Shi, Jie Liu,* Jun Li, Kang C. Zheng, Cai P. Tan, Lan M. Chen and Liang N. Ji*Electronic effect of different positions of the NO2 group on the DNA-intercalator of chiral complexes Ru(bpy)2L2+ (L = o-npip, m-npip and p-npip). Dalton Trans., 2005, 2038 -2046.（IF：3.012）(11) Ji

13、e Liu*, Wen-Jie Mei, An-Wu Xu, Shuo Shi, Cai-Ping Tan Liang-Nian Ji. Synthesis, characterization and antiviral activity against influenza virus of a series of novel manganese - substituted rare earth borotungstates heteropolyoxometalates, Antiviral Res. 2004, 62, 65-71. （IF：3.406）(12) Jie Liu*, Shuo

14、 Shi, Liang-Nian Ji, Wen-Jie Mei. Investigation on DNA binding and photo-cleavage properties of water-soluble porphyrin and metalloporphyrins. Trans. Metal Chem., 2005, 30, 684-690. (13) 刘杰*，王恩波，计亮年. 多金属盐酸盐抗病毒药物研究，化学进展, 2006,18,1,114-119(14) Wen J Mei, Ying X. Liu, Jie Liu*, Jun Li, Kang C. Zheng, L

15、iang N. Ji*, Synthesis, charcterization and DNA-binding properties of mixed porphyrin- polypyridyl ruthemun(II) complexes. Trans. Metal. Chem. 2005, 30, 82-88.(15) Liu Jie*, Mei Wen Jie, Li An Xing, Tan Cai Ping, Shi Shuo, Ji Liang Nian, Inhibition of Influenza Virus Infection in MDCK Cells by rare

16、Earth Borotungstates Heteropoly Blueswith Mixed Valence. Chem. J. Chin. Univ. 2004, 25(1):1-6. (16) Liu Jie*, Mei Wen jie, Ji Liang nian. The development of ruthenium complexes as anticancer drugs activation and anticancer mechanism. Progress in Chemistry. 2004, 16(6)：969-974. (17) Jie Liu*, Wen-Jie

17、 Mei, An-Wu Xu, Cai-Ping Tan and Liang-Nian Ji. Synthesis, characterization and antiviral activities of nickel - substituted rare earth molybdosilicic heteropoly blues. Transition Metal. Chemistry. 2003, 28:500-505.(18) Jie Liu*, Wen J. Mei, Li J. Lin, Kang C. Zheng, Hui Chao, Feng C. Yun HHand Lian

18、g N. Ji, Electronic effects on the interactions of complexes Ru(phen)2p-L2+ (L = MOPIP, HPIP and NPIP) with DNA. Inorg. Chim. Acta.2004,357, 289-293.(19) Wen J. Mei, Jie Liu, Hui Chao, An X. Li, and Liang N. Ji. DNA-binding and cleavage studies of a novel prophyrin ruthenium mixed complex MPyTPP-Ru(

19、pip)2Cl+. Transition Metal Chemistry. 2003, 28: 852-857.(20) Wen J. Mei, Jie Liu, Kang C. Zheng, li J. Lin, Hui Chao, An X. Li, Feng C. Yun and Liang N.Ji* Experimental and theoretical study on DNA-binding and photocleavage properties of chiral complexes D- and L- Ru(bpy)2L (L = o-hpip, m-hpip and p

20、-hpip) J.Chem.Soc.Dalton. Trans. 2003. 29: 2003, 1352-1359(21) Zhang Qianling, Xu Hong, Liu jie, Ji liangnian, Liu jingang. Synthesis, DNA -binding and photocleavage studies of cobalt mixed-ligand complexes. Transition Metal Chemistry. 2002, 27, 2, 149-154. (22) 梅文杰, 刘杰, 李安兴，黄绮雯，计亮年. 钌卟啉Ru(bpy)2(MPy

21、TPP)Cl+与DNA作用的研究高等学校化学学报，2002, 23 (11): 2049-2051.(23) Xiao-Hua Zou, Hong Li, Guang Yang, Hong Deng, Jie Liu, Run-Hua Li, Qian-Ling Zhang, Ya Xiong, and Liang-Nian Ji* Synthesis, Characterization, and Crystal Structure of a Functionalized Ruthenium(II) Polypyridyl Complex with Fused Triazinone as Li

22、gand. Inorg. Chem. 2001,40, 7091-7095.(24) Liu Jie*, Mei Wen-Jie, Li Yang-Guang, Wang En-Bo, Ji Liang-Nian, Tao Pei-Zhen. Antiviral activity of mixed-valence rare earth borotungstate heteropoly blues against influenza virus in mice. Antiviral Chem. Chemother. 2000, 11, 367-372.(25) Liu Jie*, Zou Xia

23、o-Hua, Mei Wen-Jie, Zhang Qian-Ling, Liu Jian-Zhong, Ji Liang-Nian. Synthesis, Characterization and antitumor activity of a series of polypyridyl complexes. Metal-Based Drugs. 2000, 7(6): 343-348.(26) 刘杰*, 许东晖, 黄锦汪, 计亮年*. 水溶性卟啉及系列金属化合物的合成、抗癌活性及作用机制的研究. 高等学校化学学报，2001,22 (9): 1446-1449 (27) Liu Jian-Z

24、hong, Huang Ying-Ying, Liu Jie, Weng Li-Ping, Ji Liang-Nian. Effects of metal ions on simultaneous production of glucose oxidase and catalase by aspergillus niger. Letters in Appied Microbiology, 2001, 32, 16-19.(28) Huang Jin-Wang, Mei Wen-Jie, Liu Jie, Ji Liang-Nian. The catalysis of some novel polystyrene-supported porphyrinatomanganese (III) in hydroxylation of cyclohexane with molecular oxygen. J. Molecular Catalysis