chapter1A Basic Concepts in Immunology

1、SmallpoxEdward JennerFather of ImmunologyInoculate with cowpox could protect smallpoxConcept of Vaccination Vaccination of cowpox against smallpoxSuccess of vaccination for eradication of smallpox in 1979Louis Pasteur 1822-1895, Father of Microbiology, attenuated bacteria and viruses as vaccine agai

2、nst anthrax .Robert Koch 1843-1910, Nobel Prize in 1905 for his work on tuberculosis, Anthrax, Cholera, Tubercule bacillusRobert KochKarl Landsteiner 1868-1943, Nobel Prize in 1930 for discovery of human blood groups (ABO types). Emil von Behring 1854 - 1917, Nobel Prize in 1901 for demonstrating th

3、at circulating antitoxins against diphtheria and tetanus toxins conferred immunity. Elvin A. Kabat 19142000Arne Wilhelm Kaurin Tiselius 19021971The Nobel Prize in Chemistry 1948FabFcAntigen binding sitePaul Ehrlich 1854-1915 Nobel Prize in 1908Rodney Porter 1915-1985The Nobel Prize in Physiology or

4、Medicine 1972Gerald M. Edelman 1929Peter Brian Medawar 19151987 The Nobel Prize in Physiology or Medicine 1960 Sir Frank Macfarlane Burnet18991985，Nobel Prize 1960 “Burnet is to immunology what Darwin is to biology” Elie Metchnikoff 1845-1916Nobel Prize in 1908 Csar MilsteinGeorges J.F. Khler 194619

5、9719222002Charles A. Janeway Jr 1943-2003The immune system Innate vs. adaptive Immunity Humoral vs. cellular immunity Systemic vs. mucosal immunityBasic Concept in Immunology The Component of the Immune System Immune cells Immune organs Primary lymphoid organs Secondary lymphoid organs Principles of

6、 Innate and Adaptive Immunity The Recognition and Effector Mechanisms of Adaptive Immunity http:/ blood cellsFigure 16.7AdherencePhagosome formationPseudopodium formationPhagolysosome formation( Fc, C receptors)(Hydrolytic enzymes)LysosomesKilling and degradationRelease digested componentshttp:/ Blood Cell Ch