阿尔茨海默症英语介绍[医学技术]

1、Alzheimers Disease阿尔茨海默症 1医疗文件Ronald Wilson ReaganRonald Wilson Reagan罗纳德罗纳德威尔逊威尔逊里根里根第第40任（第任（第49-50届）美国总统届）美国总统 president president“I know Im on my way to the twilight. I know theres always a “I know Im on my way to the twilight. I know theres always a bright dawn ahead of the United states. Thank

2、 you, my friends. bright dawn ahead of the United states. Thank you, my friends. May God bless you forever.”May God bless you forever.”2医疗文件brief introduction01PathogenyTreatment03Clinical manifestation02Other04Catalog3医疗文件brief introduction14医疗文件What?Alzheimers disease (AD) is a progressive neurode

3、generative disorder .临床症状Clinical symptom 记忆障碍dysmnesia 失语aphasia 失认agnosia 执行功能障碍executive dysfunction 痴呆dementiaThe disease usually begins after age 60, and risk goes up with age.5医疗文件Two types Alzheimers disease(AD) 65 years old senile dementia(SDAT)65 years old6医疗文件NameIn 1906,AD is named by Dr.

4、 Alois Alzheimer, a German doctor. Dr. Alzheimer noticed changes in the brain tissue of a woman who had died of an unusual mental illness.He found abnormal clumps. Scientists also have found other brain changes in people with AD.Nerve cells die in areas of the brain that are vital to memory and othe

5、r mental abilities.7医疗文件Clinical manifestation28医疗文件Clinical manifestation 期期期death1-31-3 yearsyears2-102-10 yearsyears8-12 years8-12 yearsMild dementiaMild dementiaModerate dementiaModerate dementiaSevere dementiaSevere dementiaMore women than men More women than men 7:54:67:54:6Disease for up to 1

6、0-20 yearsDisease for up to 10-20 years9医疗文件Degradation of memory and cognitionWilliam Utermohlen的自画像的自画像10医疗文件Degradation of memory and cognition William Utermohlen is an American artist, in 1995 he was diagnosed with Alzheimers disease. Since then, he has decided to take advantage of the limited t

7、ime available to retain memory and better understand himself through self portraits. William insisted the 5 New Year paintings self portrait, until completely forgotten how to draw. From the use of skilled drawing, dark portrayal of vivid features, to the same color, shape deformation, self portrait

8、 became more and more abstract (pictured above).11医疗文件Degradation of memory and cognition the effects of Alzheimers disease on the right parietal lobe of the brain are particularly severe, which directly affects the ability of the brain to visualize and develop the ability to draw pictures of the br

9、ain.said Dr. Bruce Miller, a neurologist. His work became more abstract, may be the parietal function damaged, causing blindness. What kind of changes have occurred in the brains of patients with dementia, which is not yet fully understood by the world s academia.12医疗文件PathogenyTreatment313医疗文件Patho

10、genesis hypothesis of AD14医疗文件PathogenyAbnormal amyloid beta cell deposition in neuronsAbnormal phosphorylation of tau proteinvs15医疗文件Beta amyloid (blue curve) and Tau protein (orange curve) Beta amyloid (blue curve) and Tau protein (orange curve) Research papers published Research papers published

11、in recent 30 yearsin recent 30 years16医疗文件Treatment increase the concentration of acetylcholine (Ach) in the brain promoting survival of cholinergic neurons in the brain or improving their nerve conduction function reducing the production or promoting degradation of beta amyloid17医疗文件Other418医疗文件Still AliceFilmThe f