Daunorubicin_Hydrochloride_SDS_MedChemExpress

1、Daunorubicin_Hydrochloride_SDS_MedChemExpressInhibitors, Agonists, Screening Libraries/doc/41e39b5e876fb84ae45c3b3567ec102de2bddf8e.htmlSafety Data Sheet Revision Date:May-24-2021Print Date:May-24-20211. PRODUCT AND COMPANY IDENTIFICATION1.1 Product identifierProduct name :Dau

2、norubicin (Hydrochloride)Catalog No. :HY-13062CAS No. :23541-50-61.2 Relevant identified uses of the substance or mixture and uses advised againstIdentified uses :Laboratory chemicals, manufacture of substances.1.3 Details of the supplier of the safety data sheetCompany:MedChemExpress USATel:609-228

3、-6898Fax:609-228-5909E-mail:sales/doc/41e39b5e876fb84ae45c3b3567ec102de2bddf8e.html1.4 Emergency telephone numberEmergency Phone #:609-228-68982. HAZARDS IDENTIFICATION2.1 Classification of the substance or mixtureGHS Classification in accordance with 29 CFR 1910 (OSHA HCS)Acu

4、te toxicity, Oral (Category 3), H301Respiratory sensitisation (Category 1), H334Carcinogenicity (Category 2), H3512.2 GHS Label elements, including precautionary statementsPictogramSignal word DangerHazard statement(s)H301 Toxic if swallowed.H334 May cause allergy or asthma symptoms or breathing dif

5、ficulties if inhaled.H351 Suspected of causing cancer.Precautionary statement(s)P201 Obtain special instructions before use.P202 Do not handle until all safety precautions have been read and understood.P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.P264 Wash skin thoroughly after handlin

6、g.P270 Do not eat, drink or smoke when using this product.P281 Use personal protective equipment as required.P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.P304 + P341 IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in aposition comf

7、ortable for breathing.H301 Toxic if swallowed.H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.H351 Suspected of causing cancer. P308 + P313 IF exposed or concerned: Get medical advice/ attention.P321 Specific treatment (see supplemental first aid instructions on this l

8、abel).P330 Rinse mouth.P405 Store locked up.P501 Dispose of contents/ container to an approved waste disposal plant.2.3 Other hazardsNone.3. COMPOSITION/INFORMATION ON INGREDIENTS3.1 SubstancesSynonyms:RP 13057 Hydrochloride; Daunomycin; RP13057 Hydrochloride; RP?13057 Hydrochloride; Rubidomycin hyd

9、rochlorideFormula:C27H30ClNO10Molecular Weight:563.98CAS No. :23541-50-64. FIRST AID MEASURES4.1 Description of first aid measuresEye contactRemove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate fl

10、ushing. Promptly call a physician.Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-

11、to-mouth resuscitation.IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.4.2 Most important symptoms and effects, both acute and delayedThe most important known symptoms and effects are described in the labelling (see section 2.2).4.3 Indication of any immediate medical at

12、tention and special treatment neededTreat symptomatically.5. FIRE FIGHTING MEASURES5.1 Extinguishing mediaSuitable extinguishing mediaUse water spray, dry chemical, foam, and carbon dioxide fire extinguisher.5.2 Special hazards arising from the substance or mixtureDuring combustion, may emit irritan

13、t fumes.5.3 Advice for firefightersWear self-contained breathing apparatus and protective clothing.6. ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency proceduresUse full personal protective equipment. Avoid breathing vapors, mist, dust or gas. Ensure adequate v

14、entilation. Evacuate personnel to safe areas.Refer to protective measures listed in sections 8.6.2 Environmental precautionsTry to prevent further leakage or spillage. Keep the product away from drains or water courses.6.3 Methods and materials for containment and cleaning upAbsorb solutions with fi

15、nely-powdered liquid-binding material (diatomite, universal binders); Decontaminate surfaces and equipment by scrubbing with alcohol; Dispose of contaminated material according to Section 13.7. HANDLING AND STORAGE7.1 Precautions for safe handlingAvoid inhalation, contact with eyes and skin. Avoid d

16、ust and aerosol formation. Use only in areas with appropriate exhaust ventilation.7.2 Conditions for safe storage, including any incompatibilitiesKeep container tightly sealed in cool, well-ventilated area. Keep away from direct sunlight and sources of ignition.Recommended storage temperature:Powder

17、-20C 3 years4C 2 yearsIn solvent-80C 6 months-20C 1 monthShipping at room temperature if less than 2 weeks.7.3 Specific end use(s)No data available.8. EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parametersComponents with workplace control parametersThis product contains no substances with occup

18、ational exposure limit values.8.2 Exposure controlsEngineering controlsEnsure adequate ventilation. Provide accessible safety shower and eye wash station.Personal protective equipmentEye protection Safety goggles with side-shields.Hand protection Protective gloves.Skin and body protection Impervious

19、 clothing.Respiratory protection Suitable respirator.Environmental exposure controls Keep the product away from drains, water courses or the soil. Cleanspillages in a safe way as soon as possible.9. PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical propertiesAppearance P

20、ink to red (Solid)Odor No data availableOdor threshold No data availablepH No data availableMelting/freezing point No data available Boiling point/range No data available Flash point No data available Evaporation rate No data available Flammability (solid, gas)No data available Upper/lower flammabil

21、ity or explosive limits No data available Vapor pressure No data available Vapor density No data available Relative density No data available Water Solubility No data available Partition coefficient No data available Auto-ignition temperature No data available Decomposition temperature No data avail

22、able Viscosity No data available Explosive properties No data available Oxidizing properties No data available 9.2 Other safety informationNo data available.10. STABILITY AND REACTIVITY10.1 ReactivityNo data available.10.2 Chemical stabilityStable under recommended storage conditions.10.3 Possibilit

23、y of hazardous reactionsNo data available.10.4 Conditions to avoidNo data available.10.5 Incompatible materialsStrong acids/alkalis, strong oxidising/reducing agents.10.6 Hazardous decomposition productsUnder fire conditions, may decompose and emit toxic fumes.Other decomposition products - no data

24、available.11.TOXICOLOGICAL INFORMATION11.1 Information on toxicological effectsAcute toxicityClassified based on available data. For more details, see section 2Skin corrosion/irritationClassified based on available data. For more details, see section 2Serious eye damage/irritationClassified based on

25、 available data. For more details, see section 2Respiratory or skin sensitizationClassified based on available data. For more details, see section 2Germ cell mutagenicityClassified based on available data. For more details, see section 2CarcinogenicityIARC: No component of this product present at a

26、level equal to or greater than 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.ACGIH: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by ACGIH.NTP: No component of this product present a

27、t a level equal to or greater than 0.1% is identified as a anticipated or confirmed carcinogen by NTP.OSHA: No component of this product present at a level equal to or greater than 0.1% is identified as a potential or confirmed carcinogen by OSHA.Reproductive toxicityClassified based on available da

28、ta. For more details, see section 2Specific target organ toxicity - single exposureClassified based on available data. For more details, see section 2Specific target organ toxicity - repeated exposureClassified based on available data. For more details, see section 2Aspiration hazardClassified based

29、 on available data. For more details, see section 2Additional informationRTECS No.: HB7878000May cause central nervous system depression, gastrointestinal disturbance and stomach irregularities.This information is based on our current knowledge. However the chemical, physical, and toxicological prop

30、erties have not been completely investigated.12. ECOLOGICAL INFORMATION12.1 ToxicityNo data available.12.2 Persistence and degradabilityNo data available.12.3 Bioaccumlative potentialNo data available.12.4 Mobility in soilNo data available.12.5 Results of PBT and vPvB assessmentPBT/vPvB assessment u

31、navailable as chemical safety assessment not required or not conducted.12.6 Other adverse effectsNo data available.13. DISPOSAL CONSIDERATIONS13.1 Waste treatment methodsProductDispose substance in accordance with prevailing country, federal, state and local regulations.Contaminated packagingConduct

32、 recycling or disposal in accordance with prevailing country, federal, state and local regulations.14. TRANSPORT INFORMATIONDOT (US)UN number: 2811Class: 6.1Packing group: IIIProper shipping name: Toxic solids, organic, n.o.s. (Daunorubicin HCl)Reportable Quantity (RQ):No data availableMarine pollut

33、ant: NoPoison Inhalation Hazard: NoIMDGUN number: 2811Class: 6.1Packing group: III EMS-No: F-A, S-AProper shipping name: TOXIC SOLID, ORGANIC, N.O.S. (Daunorubicin HCl)Marine pollutant: NoIATAUN number: 2811Class: 6.1Packing group: IIIProper shipping name: Toxic solid, organic, n.o.s. (Daunorubicin HCl)15. REGULATORY INFORMATIONSARA 302 Components:No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.SARA 313 Components:This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) report