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1、分享两篇 sci 发表的经历三年前对于我来说 sci 就是天书一样,在我踏进博士的门槛后我以为自己进入了地狱,也纠结也彷徨,整天刷虫友们对于博士、sci 的帖子,我选择了虫友们鼓励的那一部分来激励自己继续前行。我告诉自己坚持就是胜利,当然那是积极的坚持。在好几月之前就有这个想法,今天早上收到第二篇的接收通知后,我便想今天一定要在小木虫上谢谢那些给予我帮助的虫友们。 话不多说,我把自己这两篇投稿的经历与大家共享,希望能给大家带来一点点用处。第一篇发表在 fitoterapia cover letterdear editor verotta:we would like to submit the

2、manuscript entitled 题 目 by所有作者姓名 which we wish to be considered for publication in journal of fitoterapia.all authors have read and approved this version of the article, and due care has been taken to ensure the integrity of the work. neither the entire paper nor any part of its content has been pub

3、lished or has been accepted elsewhere. it is not being submitted to any other journal. we believe the paper may be of particular interest to the readers of your journal as it is the first time of 研究的精华所在thank you very much for your reconsidering our revised manuscript for potential publication in fi

4、toterapia. we are looking forward to hearing from you soon. correspondence should be addressed to jinhui yu at the following address, phone and fax number, and email address.地址、 学院、学校名称phone: + 86fax number: + 86571 email address: 163.combest wishes for you and your family! sincerely yours,所有作者respo

5、nse to reviewers dear editor:thank you very much for your letter and the comments from the refereesabout our paper submitted to journal of fitoterapia (fitote-d-11-01071).the manuscript entitled by 所有作者 have been revisedaccording to the reviewers comments, and we wish it to be reconsidered forpublic

6、ation in journal of fitoterapia.a list of changes and responses to reviewers are as follows. list of actionsloa1: the key words were changed in page?.loa2: the name and location of the local biochemistry company have beenadded in section 2.1 (page 3).loa3: a paragraph has been added in section 3.1 (

7、page 5) to further explainthe determination of the cis and trans configuration of double bonds inpolyprenols.loa4: the language was improved by english language editing of elsevierwebshop.to reviewer 1#,thank you very much for pointing out the problems in our manuscript. wehave revised it according

8、to your recommendations. we would like to know ifthere are still somewhere need to be amended. (1) keywords: general terms should be avoided; i would change some of thekeywords (homologues, identification, quantification)the key words have been changed as follows: 修改后关键词(2) in paragraph 2.1 the loca

9、l biochemistry company should be identified byname and location.the name and location of the local biochemistry company have been added in section 2.1 (page 3). naoh,pyrogallol,anhydrous na2so4 were purchased from hangzhou changqinghuagong co., ltd.(3) how the cis and trans configuration of double b

10、onds in were determined? authors should say something about.the following paragraph has been added in section 3.1 (page 5) to further explain the determination of the cis and trans configuration of double bonds in .(4) language should be checked for clarity and correctness.the language was improved

11、by english language editing of elsevier webshop.to reviewer 2#,thank you very much for your recommendation on our paper and we have improved by english language editing of elsevier webshop. all in all, thank you very much for your reconsidering our revised manuscript for potential publication in fit

12、oterapia. im looking forward to hearing from you soon. correspondence should be addressed to *第一作者或通讯作者at the following address, phone and fax number, and email address.地址phone: + 86571fax number: + email address: 163.com best wishes for you and your family! sincerely yours,所有作者总的来说,第一篇文章没有费很大劲。投稿后二

13、个月左右便有消息,小修后提交,第二天便接收了!那是因为这篇文章是历经磨难后的,之前投了和,其中第一个期刊当天就给我回复了,那肯定是悲剧的!编辑所谓的与该期刊不符,但我认为主要是因为文章写的太垃圾,那是我第一次写而且是没有任何人指点的情况下,可想而知会有多烂。随后这篇文章放了将近一年,填补了写数据,又投了第二个期刊,编辑委婉的拒了但给我修改重投的机会。我按照审稿人的意见和建议修改了几个月后重投(补数据,重新整结构框架,仅次于重写),结果悲剧了。而且不是因为修改的问题,而是说我的文章档次太低,不足以在上发表,我当时晕倒怎么不早说,害我这么长时间的重修。不过现在想想若不是重修在下次的投稿中又怎能如此

14、顺利呢?所以说所有的努力都不是白费的!第二篇投了 journal of ethnopharmacology,相比第一篇这个稍有磨难。也是差不多两个月的样子收到修改意见,修改后提交一直不见动静,等两个月左右的时候我有点不住了,编发了一封催稿信,之前看论坛里说忌讳催稿,但也看期刊吧,journal of ethnopharmacology 的编辑第二天便给了修改建议(还是要修改),原因是第一次修改是一个审稿人的,由于另外一个审稿人一直没给才拖到第二次。也没办法,只能再改!这次相对比较快点,每到一个月便通知接收了。journal of ethnopharmacology 与别的期刊不同,有一份 au

15、thor_checklist。不算重要但还是给大家附上附件吧(黏贴好像乱掉了),我之前也是请教的虫友。需要提醒的是初次提交和修改后要注意最后一项打勾。dear editor,we would like to submit the manuscript entitled by which we wish to be considered for publication in journal of ethnopharmacology.all authors have read and approved this version of the article, and due carehas bee

16、n taken to ensure the integrity of the work. neither the entire paper nor any part of its content has been published or has been accepted elsewhere. it is not being submitted to any other journal. we believe the paper may be of particular interest to the readers of your journal as it is the first ti

17、me of investigating correspondence should be addressed to jinhui yu at the following address, phone and fax number, and email address.地址phone: + 86fax number: + 86571 email address: 163.comthank you very much for your considering our manuscript for potential publication. im looking forward to hearin

18、g from you soon.best wishes for you and your family! sincerely yours,大同小异单独提交第一次修改a list of changes and responses to reviewers are as follows. list of actionsloa1: the reference on the selection of doses has been adapted in section 2.2 (page 5).loa2: the details of hplc data were supplemented in sec

19、tion 2.1 (page 4). loa3: figure 3, figure 4 and figure 5 have been redrawn. replies to the remarks of the reviewer 1:the authors appreciate valuable suggestions and comments from the anonymous reviewers. we have revised our manuscript accordingly. hope it issatisfactory now.(1) how the doses have be

20、en selected? if the doses have been adapted froma previous publication please cite the paper. the doses were selected according to previous studies of 。 wehave adapted the paper in our revised manuscript. (2) it would be more interesting if the authors could show the details of hplcdata in this manu

21、script. which fraction has been used to perform experiments?we have provided the hplc chromatogram of used in the animalexperiment. the fraction of the purified extract mostly consisted of ,which accounting for 0.22%, 1.06%, 5.65%, 13.96%, 10.82%, 6.70%,14.47%, 22.81%, 16.64%, 6.13%, 1.52%, respecti

22、vely. the purity of the was assessed using hplc, amounting to 85%. (3) fig 3 and 5 should be redone. photos may take by using little more higherobjectives like 32x or 40 x to show the picture clearly. scale bars should bementioned inside the figure (in right corner).we redrew the both figures. scale

23、 bars have been mentioned inside the figure3, figure 4 and figure 5. the magnification of 200 was adopted for figure 3and figure 5, referring to many previous studies (gui et al., 2006; hsieh et al.,2011; jung et al., 2012; xiao et al., 2012). the reviewers concern about theinsufficiently clear figu

24、res might result from the low resolution of the picturein our previous version. corresponding pictures with improved resolution wereprovided, which appear much clearer. we can also provide original figures if itis necessary.references:gui, s.y., wei, w., wang, h., wu, l., sun, w.y., chen, w.b. and w

25、u, c.y.,2006. effects and mechanisms of crude astragalosides fraction on liver fibrosisin rats. journal of ethnopharmacology 103: 154-159.hsieh, w.t., liu, y.t. and lin, w.c., 2011. anti-inflammatory properties ofajuga bracteosa in vivo and in vitro study and their effects on mouse modelof liver fib

26、rosis. journal of ethnopharmacology 135: 116-125.jung, h.w., jung, j.k., son, k.h., lee, d.h., kang, t.m., kim, y.s. and park,y.k., 2012. inhibitory effects of the root extract of dipsacus asperoides c.y.chengetalt.m.aioncollagen-inducedarthritisinmice.journalofethnopharmacology 139: 98-103.xiao, j.

27、, liong, e.c., ching, y.p., chang, r.c., so, k.f., fung, m.l. and tipoe,g.l., 2012. lycium barbarum polysaccharides protect mice liver from carbontetrachloride-induced oxidative stress and necroinflammation. journal ofethnopharmacology 139: 462-470.yu, j., wang, y., qian, h., zhao, y., liu, b. and f

28、u, c. polyprenols from theneedles of taxus chinensis var. mairei. fitoterapia, in revison.第二次修改a list of changes and responses to reviewers are as follows. list of actionsloa1: the description of the effect of tps (protective rather than therapeutic)in the article was corrected to avoid misunderstan

29、ding. introduction, the last sentence (paragraph 3).section 3.1, “rats treated with tps” was changed as “rats treated with bothtps and ccl4” (line 3)section 3.5, “in the livers of chronic ccl4 treated rats” was deleted by adding“in the treatment with tps+ccl4” at the head of the sentence. (line 7) d

30、iscussion, the first and the last sentence (paragraph 1).discussion, “the treatment with tps” was changed as “the treatment withtps+ccl4”(paragraph 2, line 9) discussion, the last sentence (paragraph 4) discussion, the last sentence (paragraph 5) discussion, the first sentence (paragraph 7)loa2: the

31、 figures and tables are explained in order in the main text. section 3.1, fig. 3a (line 6) was added.section 3.3, fig. 4a (line 2), fig. 4b-c (line 3) and fig. 4b (line 9) and fig.4a-b (line 10) were deleted.section 3.4, fig. 5a, f (line 3), fig. 5c-e, f (line 5) were added. loa3: figure 2 was suppl

32、emented with the standard chromatogram andconcrete information about the peaks under the figure. loa4: the petroleum was corrected into petroleum ether. loa5: the discussion section was modified.replies to the remarks of the reviewer 2:the authors appreciate valuable suggestions and comments from th

33、eanonymous reviewers. we have revised our manuscript accordingly.1. fig 6 shows that on rna expression is not dose dependent,rather different doses of has opposite effect ( fig 6 a, e,k), meansthat protein level of this gene could provide the missing links. according tome protein level along with rn

34、a level could provide an insight to themechanism of .we agree with this point. we have actually tried quantitative analyses ofrelative proteins to further clarify mechanism, as well as western-blotexperiments. these efforts, however, failed due to the technical difficulty ofremoving the lipid compos

35、ition which seriously interfere the accuracy ofprotein quantification.after the optimizationand improvement of theextraction for quite a long time, the experimental result was still notsatisfactory. however, we believe our present results could fairly although notperfectlysupportourmainconclusions.a

36、nyway,wechangedseveralinterpretations of the present results to adequately discuss the mechanisms of。2. in the conclusion, the authors claimed that the possible mechanisminvolves an anti oxidative ability. according to the table 4 data, it isevident that lipid peroxidation of 120 and 300 are same (i

37、nsignificantly different) but corresponding antioxidant enzyme activities weresignificantly differ between them.the inconsistent results between antioxidant enzyme activities and lipidperoxidation might need some explanation. as we know, the composition ofthelipidperoxidationwhichincludesmanyotherco

38、mponents(loidl-stahlhofen and spiteller, 1994) except malondialdehyde might have beenchangedunder300treatment.moreover,theantioxidantmechanism of different drugs in various organisms is completed according toprevious studies (galano et al., 2009; qian et al., 2011). we just speculatethat the anti-fi

39、brotic effect might be related with the antioxidant ability of the based on the data, while the preliminary conclusion needs furtherexperimental verifications. we have made corresponding modification on theconclusion in our manuscript. 3. i am confused with the duration of in animals. induction ofci

40、rrhosiswasdonebysubcutaneousinjectionofccl4for8weeks.simultaneous administration of drug was performed for 8weeks. can iassume that the action of drug is to prevent the induction of cirrhosis ratherthan therapeutic effect?the experiment only verified the preventive effect rather than the therapeutic

41、effect. we will consider the therapeutic effect in the next experiment. wehave corrected the description in the article to avoid misunderstanding 4. the figures and tables are not explained in order, in the main text.we have carefully checked the whole text and corrected the issues youraised. 5. fig

42、 2, chromatogram of standard is missing, explanation of different peaksare also missingwe have supplied the standard chromatogram in figure 2, and appended theparticular information of each peak, including the name of the substance andthe percentage.6. expression of p value is misleadingwe are sorry

43、 that we have not comprehended your meaning. the expressionof p value in our manuscript was referred to literatures (kim et al., 2011; liet al., 2010). 7. in the method section, instead of petroleum, petroleum ether would givebetter perception.we are sorry about the mistake. actually, we used petrol

44、eum ether in theexperiment.8.testslikeindocyaninegreenplasmadisappearancerate/monoethylglycinexylidide test would be more sensitive tests for liver functionwe selected the indicators and methods for liver function evaluationaccording to the published literature on animal experiments (li et al., 2010

45、;mu et al., 2009; takahashi et al., 2012; tipoe et al., 2010). they are also wellaccepted as indicators in this field. indocyanine green plasma disappearancerate/monoethylglycinexylidide test are mainly in clinical use. we will considerits application in our further studies.9. the mechanism of is no

46、t properly discussed.we have endeavored to sort out the mechanism of via furtherrevision of the corresponding discussion. the authors would appreciate thatreviewers could explicitly state the points in case of further concerns. wepromise to address them immediately.10. authors suggested in the limit

47、ation of the study that is nothiglypure,stillitshowsbetteractivitythanstandarddrug,notinhistopathology results.thanks for highlighting our findings. are promising natural productsdeserving further investigations. actually we are currently optimizing thepurified process to prepare high-purity for pos

48、t verificationexperiment. references:galano, a., lvarez-diduk, r., ramrez-silva, m.t., alarcn-ngeles, g. androjas-hernndez, a., 2009. role of the reacting free radicals on theantioxidantmechanism of curcumin. chemical physics 363, 13-23.kim, h.y., park, j., lee, k.h., lee, d.u., kwak, j.h., kim, y.s

49、. and lee, s.m.,2011. ferulic acid protects against carbon tetrachloride-induced liver injury inmice. toxicology 282, 104-111.li, g.s., jiang, w.l., tian, j.w., qu, g.w., zhu, h.b. and fu, f.h., 2010. invitro and in vivo antifibrotic effects of rosmarinic acid on experimental liverfibrosis. phytomed

50、icine 17, 282-288.loidl-stahlhofen, a. and spiteller, g., 1994. alpha-hydroxyaldehydes, productsof lipid peroxidation. biochim biophys acta 1211, 156-160.mu, y., liu, p., du g, du j, wang, g., long, a., wang, l. and li, f., 2009.action mechanism of yi guan jian decoction on ccl4 induced cirrhosis in rats.journal of ethnopharmacology 121, 35-42.qian,

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