Reaxys使用方法

1、December 4, 2020,Reaxys介绍和培训,Yapeng Zhang Ph.D.,December 4, 2020 Slide 2,1. Elsevier 2. 什么是Reaxys 3. Reaxys的功能举例 4 问答,目录,December 4, 2020 Slide 3,1. Elsevier,Elsevier契合用户研发流程的产品线,December 4, 2020 Slide 5,1. Elsevier 2. 什么是Reaxys 3. Reaxys的功能举例 4 问答,目录,December 4, 2020 Slide 6,34.0 Million Reactions

2、47.0 Million Substances 19.4 Million Citations 16,000 Periodicals,What exactly is Reaxys,为化学研究提供必需的研发信息(1),Reaxys所提供信息的拓展,收录范围大大扩展 与化学相关的核心的400多种期刊全面覆盖化学各个领域的16,000种相关期刊，书籍等。 收录了约5亿条相关信息 覆盖了几乎所有与合成相关的资料,収録対象大幅扩大 期刊约16,000种期刊，包括各个领域的生命科学，工程，药理学，环境科学书籍，学会文摘等,*支持定向搜索标题，摘要，关键字模式，已加入“Literature”的内容， 并可以从

3、结构式对相关文献进行搜索。,Reaxys是什么？,Slide 8,Publication In Tetrahedron,Patent,Patent,across time, documents and publishers,December 4, 2020 Slide 9,1. Elsevier 2. 什么是Reaxys 3. Reaxys的功能举例 4 问答,目录,3.1 反应的检索 ,December 4, 2020 Slide 10,Change Structure Editor Easily,3.1.1 完成一次反应检索,December 4, 2020 Slide 11,Decemb

4、er 4, 2020 Slide 12,Analysis View,December 4, 2020 Slide 13,3.1.2 Substructure Filter,December 4, 2020 Slide 14,The reactions: deprotection,December 4, 2020 Slide 15,Substructure Filter,December 4, 2020 Slide 16,Starting Materials & exclude,December 4, 2020 Slide 17,Results:,December 4, 2020 Slide 1

5、8,3.1.3 关心基团变化的模糊检索 Atom Mapping Function,December 4, 2020 Slide 19,G: Any Group,December 4, 2020 Slide 20,Atom Mapping is effective to the atoms only not groups,December 4, 2020 Slide 21,December 4, 2020 Slide 22,Results,December 4, 2020 Slide 23,3.1.4 锁定反应于一个键上 Make Bond as Reaction Center,Buildin

6、g C-C bond,December 4, 2020 Slide 24,December 4, 2020 Slide 25,December 4, 2020 Slide 26,Reaction Type,December 4, 2020 Slide 28,3.1.5 遇到互变异构体时 In tautomers,December 4, 2020 Slide 29,December 4, 2020 Slide 30,13 reactions,Comparison,December 4, 2020 Slide 31,8 reactions,December 4, 2020 Slide 32,3.1

7、.6 利用新Reaxys定制合成计划 (Synthesis Plan),December 4, 2020 Slide 33,手动生成合成计划(Manually),December 4, 2020 Slide 34,手动将反应添加至合成计划中,December 4, 2020 Slide 35,手动延续合成计划,December 4, 2020 Slide 36,将新的方程式添加至合成计划中,December 4, 2020 Slide 37,亦可继续添加直至完成,December 4, 2020 Slide 38,添加新的方程式,December 4, 2020 Slide 39,完成最终合成

8、计划,December 4, 2020 Slide 40,当完成合成计划制定时，我们还可以,December 4, 2020 Slide 41,根据反应步骤数字查询相对应的文献,December 4, 2020 Slide 42,路线所涉文献,December 4, 2020 Slide 43,查看文献中实验操作步骤,December 4, 2020 Slide 44,获取全文下载跳转链接,December 4, 2020 Slide 45,期刊自动跳转链接,December 4, 2020 Slide 46,专利全文跳转链接WO2006/136442 A1, 2006, page:37-38

9、,December 4, 2020 Slide 47,Patent Fulltext,December 4, 2020 Slide 48,Patent Fulltext,December 4, 2020 Slide 49,Download Fulltext,December 4, 2020 Slide 50,保存、导出或将合成计划添加至Reaxys报告中,December 4, 2020 Slide 51,December 4, 2020 Slide 52,3.2 物质检索 模糊物质检索,1. Pyridin with only one X substitute 2. The position

10、 of X was not certain,December 4, 2020 Slide 53,Only one X substituted. 411 substances,December 4, 2020 Slide 54,Method I,Method II,December 4, 2020 Slide 55,December 4, 2020 Slide 56,December 4, 2020 Slide 57,Only one X substituted. 411 substances,December 4, 2020 Slide 58,3.2 物质检索 Substance and Pr

11、operties,December 4, 2020 Slide 59,December 4, 2020 Slide 60,Sirolimus,December 4, 2020 Slide 61,Results,December 4, 2020 Slide 62,Single Structure,Mixture,December 4, 2020 Slide 63,December 4, 2020 Slide 64,December 4, 2020 Slide 65,December 4, 2020 Slide 66,December 4, 2020 Slide 67,Identification

12、,December 4, 2020 Slide 68,December 4, 2020 Slide 69,December 4, 2020 Slide 70,December 4, 2020 Slide 71,December 4, 2020 Slide 72,December 4, 2020 Slide 73,December 4, 2020 Slide 74,December 4, 2020 Slide 75,December 4, 2020 Slide 76,December 4, 2020 Slide 77,December 4, 2020 Slide 78,December 4, 2

13、020 Slide 79,December 4, 2020 Slide 80,Filter - 2012,December 4, 2020 Slide 81,December 4, 2020 Slide 82,December 4, 2020 Slide 83,December 4, 2020 Slide 84,December 4, 2020 Slide 85,126 substances out of 1063 citations,December 4, 2020 Slide 86,3.3.1 从物质结构到文献,December 4, 2020 Slide 87,输入结构式,选择Literature,December 4, 2020 Slide 88,结果 （83个）,3.3.2 从关键词到文献,December 4, 2020 Slide 89,December 4, 2020 Slide 90,PKC inhibitor,输入所检关键词,点击检索,December 4, 2020 Slide 91,结果（5884）,December 4, 2020 Sl